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Protein Overview: MYD88

General Information:
Name(s) found: MYD88 [HGNC (HUGO)]
Description(s) found:
Found 23 descriptions.
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  • myeloid differentiation primary response gene (88) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 296 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL AEEMDFEYLE  60
   61 IRQLETQADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD VLLELGPSIE EDCQKYILKQ 120
  121 QQEEAEKPLQ VAAVDSSVPR TAELAGITTL DDPLGHMPER FDAFICYCPS DIQFVQEMIR 180
  181 QLEQTNYRLK LCVSDRDVLP GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA 240
  241 LSLSPGAHQK RLIPIKYKAM KKEFPSILRF ITVCDYTNPC TKSWFWTRLA KALSLP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] PSI-BLAST 25.154902 Crystal structure of the UNC5H2 death domain
    2 View Details [153..296] PSI-BLAST 35.221849 Toll-like receptor 2, TLR2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  3.50518632995622 bayes_pls_golite062009
  • binding
    		•  2.81925838257497 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.66783807193588 bayes_pls_golite062009
  • receptor activity
    		•  1.49139108045528 bayes_pls_golite062009
  • enzyme binding
    		•  0.78444772609923 bayes_pls_golite062009
  • tumor necrosis factor binding
    		•  0.732234543123958 bayes_pls_golite062009
  • death receptor activity
    		•  0.627802739213643 bayes_pls_golite062009
  • apoptotic protease activator activity
    		•  0.487782160925381 bayes_pls_golite062009
  • tumor necrosis factor receptor activity
    		•  0.428938788578756 bayes_pls_golite062009
  • Pyrin domain binding
    		•  0.307516801321075 bayes_pls_golite062009
  • identical protein binding
    		•  0.206123549797411 bayes_pls_golite062009
  • signal transducer activity
    		•  0.201651915574531 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.201651915574531 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.151782936408674 bayes_pls_golite062009
  • death domain binding
    		•  0.119918387246423 bayes_pls_golite062009
  • cytokine binding
    		•  0.0519010687665362 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.0460645022887266 bayes_pls_golite062009
  • catalytic activity
    		•  0.043183590691418 bayes_pls_golite062009
    2
    Term Confidence Notes
  • double-stranded RNA binding
    		•  4.32086914489227 bayes_pls_golite062009
  • siRNA binding
    		•  3.8837709376582 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.46815521682665 bayes_pls_golite062009
  • binding
    		•  2.31499720771829 bayes_pls_golite062009
  • protein binding
    		•  2.10005190551596 bayes_pls_golite062009
  • receptor activity
    		•  1.91178122133017 bayes_pls_golite062009
    		• 1.86047705807897 bayes_pls_golite062009
  • lipopolysaccharide binding
    		•  1.79927076993237 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.68133457503491 bayes_pls_golite062009
  • DNA binding
    		•  1.10666978727222 bayes_pls_golite062009
  • RNA binding
    		•  0.964496567264848 bayes_pls_golite062009
  • signal transducer activity
    		•  0.574489626172021 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.574489626172021 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.0787292540642052 bayes_pls_golite062009
  • growth factor activity
    		•  0.0066769104515047 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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