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Protein Overview: LIG4

General Information:
Name(s) found: LIG4 [HGNC (HUGO)]
Description(s) found:
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  • gi|88911290|sp|P49917.2|DNLI4_HUMAN RecName: Full=DNA ligase 4; AltName: Full=DNA ligase IV; AltName: Full=Polydeoxyribonucleotide synthase [ATP] 4 [NCBI NR]
  • gi|55661814|emb|CAH70629.1| ligase IV, DNA, ATP-dependent [Homo sapiens] [NCBI NR]
  • gi|46255052|ref|NP_996820.1| DNA ligase IV [Homo sapiens] [NCBI NR]
  • gi|23199993|ref|NP_002303.2| DNA ligase IV [Homo sapiens] [NCBI NR]
  • gi|22766796|gb|AAH37491.1| Ligase IV, DNA, ATP-dependent [Homo sapiens] [NCBI NR]
  • gi|148539894|ref|NP_001091738.1| DNA ligase IV [Homo sapiens] [NCBI NR]
  • gi|119629501|gb|EAX09096.1| ligase IV, DNA, ATP-dependent, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119629500|gb|EAX09095.1| ligase IV, DNA, ATP-dependent, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119629499|gb|EAX09094.1| ligase IV, DNA, ATP-dependent, isoform CRA_a [Homo sapiens] [NCBI NR]
  • ligase IV, DNA, ATP-dependent [HGNC (HUGO)]
  • DNA ligase 4 OS=Homo sapiens GN=LIG4 PE=1 SV=2 [Swiss-Prot]
  • DNA ligase 4 - Homo sapiens (Human) [Swiss-Prot]
  • Ligase IV, DNA, ATP-dependent [hmr_yeast5_DM3-1_pombe.fasta]
  • DNA ligase IV; polydeoxyribonucleotide synthase; polynucleotide ligase; Sealase; DNA repair enzyme; DNA joinase [HMR_022704.fasta]
  • DNA ligase IV [Homo sapiens]gi|23199993|ref|NP_002303.2| DNA ligase IV [Homo sapiens]gi|55661814|emb|CAH70629.1| ligase IV, DNA, ATP-dependent [Homo sapiens]gi|22766796|gb|AAH37491.1| DNA ligase IV [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 DNA ligase 4 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • DNA ligase IV [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 DNA ligase IV [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • DNA ligase IV; polydeoxyribonucleotide synthase; polynucleotide ligase; Sealase; DNA repair enzyme; DNA joinase [Homo sapiens] [HumanGallus06162005.fasta]
  • DNA ligase 4 (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ligase IV, DNA, ATP-dependent [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ligase IV, DNA, ATP-dependent, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ligase IV, DNA, ATP-dependent [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 DNA LIGASE IV [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LIG4 DNA ligase 4 [human-ipi-250309-contam.fasta]
  • DNA ligase (ATP) 4 [Homo sapiens] [NCBI-RefSeq_Human_na_02-15-2010_reversed.fasta]
  • IPI:IPI00217669.1|SWISS-PROT:P49917|TREMBL:A8K8Q4;B2RBW4|ENSEMBL:ENSP00000349393;ENSP00000385955;ENSP00000402030|REFSEQ:NP_001091738;NP_002303;NP_996820|H-INV:HIT000051922|VEGA:OTTHUMP00000018690 Tax_Id=9606 Gene_Symbol=LIG4 DNA ligase 4 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=LIG4 DNA ligase 4 ENSG00000174405 IPI00217669 [drosphohumanreversed.fasta]
  • DNA ligase 4 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P49917;Q8IY66;Q8TEU5; RecName: Full=DNA ligase 4; AltName: Full=DNA ligase IV; AltName: Full=Polydeoxyribonucleotide synthase [ATP] 4; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • DNA ligase 4 OS=Homo sapiens GN=LIG4 [011711_HMR.fasta]
  • GeneSymbol=LIG4 Synonyms=- DNA ligase 4 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • DNA ligase 4 GN=LIG4 [Doctor+uniprot-HUMAN-120911.fasta]
  • DNA ligase OS=Homo sapiens GN=LIG4 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 911 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFR EFLDSWRKFH DALHKNHKDV  60
   61 TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RDGKDALKLL NYRTPTGTHG 120
  121 DAGDFAMIAY FVLKPRCLQK GSLTIQQVND LLDSIASNNS AKRKDLIKKS LLQLITQSSA 180
  181 LEQKWLIRMI IKDLKLGVSQ QTIFSVFHND AAELHNVTTD LEKVCRQLHD PSVGLSDISI 240
  241 TLFSAFKPML AAIADIEHIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYKY FSRNGYNYTD 300
  301 QFGASPTEGS LTPFIHNAFK ADIQICILDG EMMAYNPNTQ TFMQKGTKFD IKRMVEDSDL 360
  361 QTCYCVFDVL MVNNKKLGHE TLRKRYEILS SIFTPIPGRI EIVQKTQAHT KNEVIDALNE 420
  421 AIDKREEGIM VKQPLSIYKP DKRGEGWLKI KPEYVSGLMD ELDILIVGGY WGKGSRGGMM 480
  481 SHFLCAVAEK PPPGEKPSVF HTLSRVGSGC TMKELYDLGL KLAKYWKPFH RKAPPSSILC 540
  541 GTEKPEVYIE PCNSVIVQIK AAEIVPSDMY KTGCTLRFPR IEKIRDDKEW HECMTLDDLE 600
  601 QLRGKASGKL ASKHLYIGGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLT NVNKISNIFE 660
  661 DVEFCVMSGT DSQPKPDLEN RIAEFGGYIV QNPGPDTYCV IAGSENIRVK NIILSNKHDV 720
  721 VKPAWLLECF KTKSFVPWQP RFMIHMCPST KEHFAREYDC YGDSYFIDTD LNQLKEVFSG 780
  781 IKNSNEQTPE EMASLIADLE YRYSWDCSPL SMFRRHTVYL DSYAVINDLS TKNEGTRLAI 840
  841 KALELRFHGA KVVSCLAEGV SHVIIGEDHS RVADFKAFRR TFKRKFKILK ESWVTDSIDK 900
  901 CELQEENQYL I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..650] PSI-BLAST 145.0 Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
    2 View Details [651..809] PSI-BLAST 25.69897 No description for 2e2wA was found.
    3 View Details [810..911] PSI-BLAST 3.522879 Breast cancer associated protein, BRCA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA ligase activity
    		•  10.0279903057926 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  9.92846900587219 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  8.51283882444113 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  3.1488483282989 bayes_pls_golite062009
  • ligase activity
    		•  2.36807839237461 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • binding
    		•  1.82998145778732 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.4725380374617 bayes_pls_golite062009
  • protein binding
    		•  1.38006517521813 bayes_pls_golite062009
  • DNA binding
    		•  1.1855473374207 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.316166307022498 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle