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Protein Overview: RTN4R

General Information:
Name(s) found: RTN4R [HGNC (HUGO)]
Description(s) found:
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  • gi|47678251|emb|CAG30246.1| Em:AC007663.1 [Homo sapiens] [NCBI NR]
  • gi|37181714|gb|AAQ88664.1| NOGOR [Homo sapiens] [NCBI NR]
  • gi|25453267|sp|Q9BZR6.1|RTN4R_HUMAN RecName: Full=Reticulon-4 receptor; AltName: Full=Nogo receptor; Short=NgR; AltName: Full=Nogo-66 receptor; Flags: Precursor [NCBI NR]
  • gi|21740193|emb|CAD39109.1| hypothetical protein [Homo sapiens] [NCBI NR]
  • gi|15080005|gb|AAH11787.1| Reticulon 4 receptor [Homo sapiens] [NCBI NR]
  • gi|13194201|ref|NP_075380.1| reticulon 4 receptor precursor [Homo sapiens] [NCBI NR]
  • gi|12407653|gb|AAG53612.1|AF283463_1 Nogo receptor [Homo sapiens] [NCBI NR]
  • gi|119623381|gb|EAX02976.1| reticulon 4 receptor, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119623380|gb|EAX02975.1| reticulon 4 receptor, isoform CRA_a [Homo sapiens] [NCBI NR]
  • reticulon 4 receptor [HGNC (HUGO)]
  • Reticulon-4 receptor OS=Homo sapiens GN=RTN4R PE=1 SV=1 [Swiss-Prot]
  • (Q9BZR6) Reticulon 4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor) (UNQ330/PRO526) [Swiss-Prot]
  • Reticulon 4 receptor precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • reticulon 4 receptor; nogo receptor [HMR_022704.fasta]
  • reticulon 4 receptor precursor; nogo receptor; Nogo-66 receptor; UNQ330/PRO526 [071204_hmrz_cont.fasta]
  • NOGOR [Homo sapiens]gi|13194201|ref|NP_075380.1| reticulon 4 receptor precursor [Homo sapiens]gi|15080005|gb|AAH11787.1| Reticulon 4 receptor precursor [Homo sapiens]gi|21740193|emb|CAD39109.1| hypothetical protein [Homo sapiens]gi|12407653|gb|AAG5361 [nrdb_11152004_Chlamydomonas]
  • Reticulon 4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Reticulon-4 receptor precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_023004) reticulon 4 receptor; nogo receptor [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • reticulon 4 receptor precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Reticulon 4 receptor precursor [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • reticulon 4 receptor precursor; nogo receptor; Nogo-66 receptor; UNQ330/PRO526 [Homo sapiens] [HumanGallus06162005.fasta]
  • reticulon 4 receptor; nogo receptor [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Em:AC007663.1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • reticulon 4 receptor, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Reticulon 4 receptor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hypothetical protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • NOGOR [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Nogo receptor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 RETICULON 4 RECEPTOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=RTN4R Reticulon-4 receptor [human-ipi-250309-contam.fasta]
  • IPI:IPI00289204.3|SWISS-PROT:Q9BZR6|ENSEMBL:ENSP00000043402;ENSP00000385182|REFSEQ:NP_075380|H-INV:HIT000252341|VEGA:OTTHUMP00000028609;OTTHUMP00000197856;OTTHUMP00000197866 Tax_Id=9606 Gene_Symbol=RTN4R Reticulon-4 receptor [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=RTN4R Reticulon-4 receptor precursor ENSG00000040608 IPI00289204 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=RTN4R Reticulon-4 receptor precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • reticulon-4 receptor precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9BZR6; RecName: Full=Reticulon-4 receptor; AltName: Full=Nogo receptor; AltName: Full=Nogo-66 receptor; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Reticulon-4 receptor OS=Homo sapiens GN=RTN4R [011711_HMR.fasta]
  • IPI:IPI00289204.3|SWISS-PROT:Q9BZR6|TREMBL:D3DX28|ENSEMBL:ENSP00000043402;ENSP00000385182|REFSEQ:NP_075380|H-INV:HIT000252341|VEGA:OTTHUMP00000028609;OTTHUMP00000197856;OTTHUMP00000197866 Tax_Id=9606 Gene_Symbol=RTN4R Reticulon-4 receptor [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=RTN4R Synonyms=NGR|NOGOR reticulon-4 receptor precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00289204.3|SWISS-PROT:Q9BZR6|ENSEMBL:ENSP00000043402|REFSEQ:NP_075380|H-INV:HIT000252341|VEGA:OTTHUMP00000197856 Tax_Id=9606 Gene_Symbol=RTN4R Reticulon-4 receptor [ipi.HUMAN.20110912.fasta]
  • Reticulon-4 receptor GN=RTN4R [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRASAGGSR LLAWVLWLQA WQVAAPCPGA CVCYNEPKVT TSCPQQGLQA VPVGIPAASQ  60
   61 RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA FTGLALLEQL DLSDNAQLRS 120
  121 VDPATFHGLG RLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNALQALP DDTFRDLGNL 180
  181 THLFLHGNRI SSVPERAFRG LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFANNLSA 240
  241 LPTEALAPLR ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR 300
  301 LAANDLQGCA VATGPYHPIW TGRATDEEPL GLPKCCQPDA ADKASVLEPG RPASAGNALK 360
  361 GRVPPGDSPP GNGSGPRHIN DSPFGTLPGS AEPPLTAVRP EGSEPPGFPT SGPRRRPGCS 420
  421 RKNRTRSHCR LGQAGSGGGG TGDSEGSGAL PSLTCSLTPL GLALVLWTVL GPC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..333] PSI-BLAST 42.0 Reticulon 4 receptor (Nogo-66 receptor, Ngr)
    2 View Details [334..473] MSA 1.650988 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • extracellular matrix structural constituent
    		•  2.72113902188155 bayes_pls_golite062009
  • receptor activity
    		•  1.88785535225324 bayes_pls_golite062009
  • binding
    		•  1.87302803330255 bayes_pls_golite062009
  • signal transducer activity
    		•  1.69338277273283 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69338277273283 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.60129047457824 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.28988458709664 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.907118880836251 bayes_pls_golite062009
  • protein binding
    		•  0.646159692466759 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.61188190229906 bayes_pls_golite062009
  • receptor binding
    		•  0.525216740013984 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.39590205214035 bayes_pls_golite062009
  • pattern binding
    		•  0.389630581129679 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.343717562511172 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.246718758617065 bayes_pls_golite062009
  • collagen binding
    		•  0.085405748322021 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle