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View Structure Prediction Details

Protein: RTN4R
Organism: Homo sapiens
Length: 473 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RTN4R.

Description E-value Query
Range
Subject
Range
gi|113535187, gi... - gi|50904693|ref|XP_463835.1| putative CLAVATA1 receptor kinase [Oryza sativa (japonica cultivar-grou...
3.0E-87 [3..472] [112..591]
gi|24940244 - gi|24940244|emb|CAD42181.1| serine-threonine protein kinase [Pisum sativum]
2.0E-81 [3..469] [110..586]

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Predicted Domain #1
Region A:
Residues: [1-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRASAGGSR LLAWVLWLQA WQVAAPCPGA CVCYNEPKVT TSCPQQGLQA VPVGIPAASQ  60
   61 RIFLHGNRIS HVPAASFRAC RNLTILWLHS NVLARIDAAA FTGLALLEQL DLSDNAQLRS 120
  121 VDPATFHGLG RLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNALQALP DDTFRDLGNL 180
  181 THLFLHGNRI SSVPERAFRG LHSLDRLLLH QNRVAHVHPH AFRDLGRLMT LYLFANNLSA 240
  241 LPTEALAPLR ALQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCSLP QRLAGRDLKR 300
  301 LAANDLQGCA VATGPYHPIW TGRATDEEPL GLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.0
Match: 1oznA
Description: Reticulon 4 receptor (Nogo-66 receptor, Ngr)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
extracellular matrix structural constituent 2.72113902188155 bayes_pls_golite062009
receptor activity 1.88785535225324 bayes_pls_golite062009
binding 1.87302803330255 bayes_pls_golite062009
signal transducer activity 1.69338277273283 bayes_pls_golite062009
molecular transducer activity 1.69338277273283 bayes_pls_golite062009
transmembrane receptor activity 1.60129047457824 bayes_pls_golite062009
glycosaminoglycan binding 1.28988458709664 bayes_pls_golite062009
extracellular matrix binding 0.907118880836251 bayes_pls_golite062009
protein binding 0.646159692466759 bayes_pls_golite062009
polysaccharide binding 0.61188190229906 bayes_pls_golite062009
receptor binding 0.525216740013984 bayes_pls_golite062009
G-protein coupled receptor activity 0.39590205214035 bayes_pls_golite062009
pattern binding 0.389630581129679 bayes_pls_golite062009
carbohydrate binding 0.343717562511172 bayes_pls_golite062009
nucleic acid binding 0.246718758617065 bayes_pls_golite062009
collagen binding 0.085405748322021 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [334-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KCCQPDAADK ASVLEPGRPA SAGNALKGRV PPGDSPPGNG SGPRHINDSP FGTLPGSAEP  60
   61 PLTAVRPEGS EPPGFPTSGP RRRPGCSRKN RTRSHCRLGQ AGSGGGGTGD SEGSGALPSL 120
  121 TCSLTPLGLA LVLWTVLGPC 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle