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Protein Overview: CDC21

General Information:
Name(s) found: CDC21 / YOR074C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: DNA-dependent DNA replication [TAS]
    dTMP biosynthetic process [TAS]
    Molecular Function: thymidylate synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMDGKNKEE EQYLDLCKRI IDEGEFRPDR TGTGTLSLFA PPQLRFSLRD DTFPLLTTKK  60
   61 VFTRGIILEL LWFLAGDTDA NLLSEQGVKI WDGNGSREYL DKMGFKDRKV GDLGPVYGFQ 120
  121 WRHFGAKYKT CDDDYTGQGI DQLKQVIHKL KTNPYDRRII MSAWNPADFD KMALPPCHIF 180
  181 SQFYVSFPKE GEGSGKPRLS CLLYQRSCDM GLGVPFNIAS YALLTRMIAK VVDMEPGEFI 240
  241 HTLGDAHVYK DHIDALKEQI TRNPRPFPKL KIKRDVKDID DFKLTDFEIE DYNPHPRIQM 300
  301 KMSV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CDC21 GTT2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CDC21 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71]
    [142..162]
    [177..304]    		 PSI-BLAST 1339.0 Thymidylate synthase
    2 View Details [72..141]
    [163..176]    		 PSI-BLAST 1339.0 Thymidylate synthase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle