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Protein Overview: STE11

General Information:
Name(s) found: STE11 / YLR362W [SGD]
Description(s) found:
Found 12 descriptions.
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  • Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 738 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: activation of MAPKK activity [IDALink to PubMed article][IMPLink to PubMed article]
    MAPKKK cascade involved in osmosensory signaling pathway [IGILink to PubMed article][IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    osmosensory signaling pathway via Sho1 osmosensor [IGILink to PubMed article]
    invasive growth in response to glucose limitation [IMPLink to PubMed article]
    signal transduction during filamentous growth [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article][IMPLink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: SAM domain binding [IDALink to PubMed article]
    MAP kinase kinase kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKERPLNKA SMIRSPVDEI YMEQTQTAEG TDLLIGDEKT NDLPFVQLFL EEIGCTQYLD  60
   61 SFIQCNLVTE EEIKYLDKDI LIALGVNKIG DRLKILRKSK SFQRDKRIEQ VNRLKNLMEK 120
  121 VSSLSTATLS MNSELIPEKH CVIFILNDGS AKKVNVNGCF NADSIKKRLI RRLPHELLAT 180
  181 NSNGEVTKMV QDYDVFVLDY TKNVLHLLYD VELVTICHAN DRVEKNRLIF VSKDQTPSDK 240
  241 AISTSKKLYL RTLSALSQVG PSSSNLLAQN KGISHNNAEG KLRIDNTEKD RIRQIFNQRP 300
  301 PSEFISTNLA GYFPHTDMKR LQKTMRESFR HSARLSIAQR RPLSAESNNI GDILLKHSNA 360
  361 VDMALLQGLD QTRLSSKLDT TKIPKLAHKR PEDNDAISNQ LELLSVESGE EEDHDFFGED 420
  421 SDIVSLPTKI ATPKNWLKGA CIGSGSFGSV YLGMNAHTGE LMAVKQVEIK NNNIGVPTDN 480
  481 NKQANSDENN EQEEQQEKIE DVGAVSHPKT NQNIHRKMVD ALQHEMNLLK ELHHENIVTY 540
  541 YGASQEGGNL NIFLEYVPGG SVSSMLNNYG PFEESLITNF TRQILIGVAY LHKKNIIHRD 600
  601 IKGANILIDI KGCVKITDFG ISKKLSPLNK KQNKRASLQG SVFWMSPEVV KQTATTAKAD 660
  661 IWSTGCVVIE MFTGKHPFPD FSQMQAIFKI GTNTTPEIPS WATSEGKNFL RKAFELDYQY 720
  721 RPSALELLQH PWLDAHII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] ORFEUS 9.89 EphA4 receptor tyrosine kinases
    2 View Details [137..232] PSI-BLAST 13.69897 pak1 autoregulatory domain
    3 View Details [233..369] deduced N/A No confident structure predictions are available.
    4 View Details [370..556] PSI-BLAST 480.457575 pak1
    5 View Details [557..738] PSI-BLAST 480.457575 pak1


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle