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Protein Overview: PCH2

General Information:
Name(s) found: PCH2 / YBR186W [SGD]
Description(s) found:
Found 10 descriptions.
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  • Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 536 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [TASLink to PubMed article]
    Biological Process: regulation of meiosis [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYIVDLQVR GSSLRVIKCM FREDEQISSL HSGSDSKQNS NKKLGEFLNL LKAVVKRKLE  60
   61 SFPKDRLKTS IITGQELMRE GQGSIEIKDP PTEAQQHLIR SLAKVLLHQF SSINGKVNTV 120
  121 NEGQDNLFLS LFVKKISIEQ QSTSHVSIKL NFHEKINLGQ HIDSILDSEE TNESDTYHMG 180
  181 SVDEFIIYPF CCLEEQDELK NGSILSTEFD KIDLELDEDD GFEGETLNNC INSVGNFDIP 240
  241 LSKQTLNLVN ISYLPGTTFE GQWESLYFGN NIKERLYSYA TISLKIARFK QTGDSNQEDI 300
  301 TTLITNNKLL LVHGPPGTGK TTLCKALCQK LSVRREFSDG SDTIDTNYKG IIIELSCARI 360
  361 FSKWFGESSK NISIVFKDIE ELLKVNEGRG IFICLLIDEV EAIASSRTNL SSRNESTDGI 420
  421 RVVNTLLTQL DRLKKYHNFL ALATSNLLDS LDDAFVDRAD GVFYVGNPTA EGILHILKVC 480
  481 IEEMITSGII LFHARSTGVK FFNKYQDILR KIAIKCSVCF FLLFYFYDSF SFFPSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..221] MSA 1.31697 View MSA. No confident structure predictions are available.
    2 View Details [222..467] PSI-BLAST 177.69897 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    3 View Details [468..536] PSI-BLAST 177.69897 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.51

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle