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Protein Overview: NFS1

General Information:
Name(s) found: NFS1 / YCL017C [SGD]
Description(s) found:
Found 6 descriptions.
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  • Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 497 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IMPLink to PubMed article][ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article]
    iron-sulfur cluster assembly [IDALink to PubMed article][ISSLink to PubMed article][TASLink to PubMed article]
    Molecular Function: tRNA sulfurtransferase activity [IMPLink to PubMed article]
    cysteine desulfurase activity [IDALink to PubMed article]
    cystathionine gamma-lyase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKSTATRSI TRLSQVYNVP AATYRACLVS RRFYSPPAAG VKLDDNFSLE THTDIQAAAK  60
   61 AQASARASAS GTTPDAVVAS GSTAMSHAYQ ENTGFGTRPI YLDMQATTPT DPRVLDTMLK 120
  121 FYTGLYGNPH SNTHSYGWET NTAVENARAY VAKMINADPK EIIFTSGATE SNNMVLKGVP 180
  181 RFYKKTKKHI ITTRTEHKCV LEAARAMMKE GFEVTFLNVD DQGLIDLKEL EDAIRPDTCL 240
  241 VSVMAVNNEI GVIQPIKEIG AICRKNKIYF HTDAAQAYGK IHIDVNEMNI DLLSISSHKI 300
  301 YGPKGIGAIY VRRRPRVRLE PLLSGGGQER GLRSGTLAPP LVAGFGEAAR LMKKEFDNDQ 360
  361 AHIKRLSDKL VKGLLSAEHT TLNGSPDHRY PGCVNVSFAY VEGESLLMAL RDIALSSGSA 420
  421 CTSASLEPSY VLHALGKDDA LAHSSIRFGI GRFSTEEEVD YVVKAVSDRV KFLRELSPLW 480
  481 EMVQEGIDLN SIKWSGH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle