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Protein Overview: TPK1

General Information:
Name(s) found: TPK1 / YJL164C [SGD]
Description(s) found:
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  • gi|173009|gb|AAA35164.1| cAMP-dependent protein kinase subunit (put.); putative [NCBI NR]
  • gi|172175|gb|AAA34877.1| protein kinase [NCBI NR]
  • gi|125208|sp|P06244.1|KAPA_YEAST RecName: Full=cAMP-dependent protein kinase type 1; Short=PKA 1; AltName: Full=CDC25-suppressing protein kinase; AltName: Full=PK-25 [NCBI NR]
  • cAMP-dependent protein kinase type 1 OS=Saccharomyces cerevisiae GN=TPK1 PE=1 SV=1 [Swiss-Prot]
  • cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p [SGD]
  • (P06244) cAMP-dependent protein kinase type 1 (EC 2.7.1.37) (PKA 1) (CDC25 suppressing protein kinase) (PK-25) [4932.FASTACCERV.txt]
  • cAMP-dependent protein kinase type 1 (PKA 1) (CDC25 suppressing protein kinase) (PK-25)gi|173009|gb|AAA35164.1| cAMP-dependent protein kinase subunit (put.); putativegi|172175|gb|AAA34877.1| protein kinase [nrdb_11152004_Chlamydomonas]
  • cAMP-dependent protein kinase subunit (put.); putative [nr-271106-contam.fasta]
  • protein kinase [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase type 1 (PKA 1) (CDC25-suppressing protein kinase) (PK-25) [nr-271106-contam.fasta]
  • [S288C.fasta]
  • cAMP-dependent protein kinase type 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPK1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TPK1 SGDID:S000003700, Chr X from 111159-109966, Genome Release 64-1-1, reverse complement, Verified ORF, "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p" [yeast-030211-contam.fasta]
  • TPK1 SGDID:S000003700, Chr X from 111159-109966, Genome Release 64-2-1, reverse complement, Verified ORF, "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YJL164C SGDID:S000003700, Chr X from 111159-109966, Genome Release 64-1-1, reverse complement, Verified ORF, "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 397 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    cAMP-dependent protein kinase complex [IMPLink to PubMed article][TASLink to PubMed article]
    Biological Process: pseudohyphal growth [IMPLink to PubMed article]
    Ras protein signal transduction [IMPLink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    Molecular Function: cAMP-dependent protein kinase activity [TASLink to PubMed article]
    protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEEQNGGG QKSLDDRQGE ESQKGETSER ETTATESGNE SKSVEKEGGE TQEKPKQPHV  60
   61 TYYNEEQYKQ FIAQARVTSG KYSLQDFQIL RTLGTGSFGR VHLIRSRHNG RYYAMKVLKK 120
  121 EIVVRLKQVE HTNDERLMLS IVTHPFIIRM WGTFQDAQQI FMIMDYIEGG ELFSLLRKSQ 180
  181 RFPNPVAKFY AAEVCLALEY LHSKDIIYRD LKPENILLDK NGHIKITDFG FAKYVPDVTY 240
  241 TLCGTPDYIA PEVVSTKPYN KSIDWWSFGI LIYEMLAGYT PFYDSNTMKT YEKILNAELR 300
  301 FPPFFNEDVK DLLSRLITRD LSQRLGNLQN GTEDVKNHPW FKEVVWEKLL SRNIETPYEP 360
  361 PIQQGQGDTS QFDKYPEEDI NYGVQGEDPY ADLFRDF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle