Protein Overview: MIP1

General Information:
Name(s) found:	MIP1 / YOR330C [SGD]
Description(s) found: Found 21 descriptions. SHOW ALL	Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases [SGD]
Organism:	Saccharomyces cerevisiae
Length:	1254 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ]
Biological Process:	DNA-dependent DNA replication [IDA][IMP] mitochondrial DNA replication [IDA]
Molecular Function:	nucleic acid binding [IEA] DNA binding [IEA] DNA-directed DNA polymerase activity [IEA][TAS] nucleotidyltransferase activity [IEA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKLMVRSEC MLRMVRRRPL RVQFCARWFS TKKNTAEAPR INPVGIQYLG ESLQRQVFGS  60
   61 CGGKDEVEQS DKLMELSKKS LKDHGLWGKK TLITDPISFP LPPLQGRSLD EHFQKIGRFN 120
  121 SEPYKSFCED KFTEMVARPA EWLRKPGWVK YVPGMAPVEV AYPDEELVVF DVETLYNVSD 180
  181 YPTLATALSS TAWYLWCSPF ICGGDDPAAL IPLNTLNKEQ VIIGHNVAYD RARVLEEYNF 240
  241 RDSKAFFLDT QSLHIASFGL CSRQRPMFMK NNKKKEAEVE SEVHPEISIE DYDDPWLNVS 300
  301 ALNSLKDVAK FHCKIDLDKT DRDFFASTDK STIIENFQKL VNYCATDVTA TSQVFDEIFP 360
  361 VFLKKCPHPV SFAGLKSLSK CILPTKLNDW NDYLNSSESL YQQSKVQIES KIVQIIKDIV 420
  421 LLKDKPDFYL KDPWLSQLDW TTKPLRLTKK GVPAKCQKLP GFPEWYRQLF PSKDTVEPKI 480
  481 TIKSRIIPIL FKLSWENSPV IWSKESGWCF NVPHEQVETY KAKNYVLADS VSQEEEEIRT 540
  541 HNLGLQCTGV LFKVPHPNGP TFNCTNLLTK SYNHFFEKGV LKSESELAHQ ALQINSSGSY 600
  601 WMSARERIQS QFVVPSCKFP NEFQSLSAKS SLNNEKTNDL AIIIPKIVPM GTITRRAVEN 660
  661 AWLTASNAKA NRIGSELKTQ VKAPPGYCFV GADVDSEELW IASLVGDSIF NVHGGTAIGW 720
  721 MCLEGTKNEG TDLHTKTAQI LGCSRNEAKI FNYGRIYGAG AKFASQLLKR FNPSLTDEET 780
  781 KKIANKLYEN TKGKTKRSKL FKKFWYGGSE SILFNKLESI AEQETPKTPV LGCGITYSLM 840
  841 KKNLRANSFL PSRINWAIQS SGVDYLHLLC CSMEYIIKKY NLEARLCISI HDEIRFLVSE 900
  901 KDKYRAAMAL QISNIWTRAM FCQQMGINEL PQNCAFFSQV DIDSVIRKEV NMDCITPSNK 960
  961 TAIPHGEALD INQLLDKSNS KLGKPNLDID SKVSQYAYNY REPVFEEYNK SYTPEFLKYF1020
 1021 LAMQVQSDKR DVNRLEDEYL RECTSKEYAR DGNTAEYSLL DYIKDVEKGK RTKVRIMGSN1080
 1081 FLDGTKNAKA DQRIRLPVNM PDYPTLHKIA NDSAIPEKQL LENRRKKENR IDDENKKKLT1140
 1141 RKKNTTPMER KYKRVYGGRK AFEAFYECAN KPLDYTLETE KQFFNIPIDG VIDDVLNDKS1200
 1201 NYKKKPSQAR TASSSPIRKT AKAVHSKKLP ARKSSTTNRN LVELERDITI SREY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	MIP1	Huh WK, et al. (2003)
View Data	MIP1	Huh WK, et al. (2003)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MIP1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: