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Protein Overview: APE2

General Information:
Name(s) found: APE2 / YKL157W [SGD]
Description(s) found:
Found 13 descriptions.
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  • Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 844 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cell wall-bounded periplasmic space [NASLink to PubMed article]
    Biological Process: peptide metabolic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: leucyl aminopeptidase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKTPNREI LPDNVVPLHY DLTVEPDFKT FKFEGSVKIE LKINNPAIDT VTLNTVDTDI  60
   61 HSAKIGDVTS SEIISEEEQQ VTTFAFPKGT MSSFKGNAFL DIKFTGILND NMAGFYRAKY 120
  121 EDKLTGETKY MATTQMEPTD ARRAFPCFDE PNLKASFAIT LVSDPSLTHL SNMDVKNEYV 180
  181 KDGKKVTLFN TTPKMSTYLV AFIVAELKYV ESKNFRIPVR VYATPGNEKH GQFAADLTAK 240
  241 TLAFFEKTFG IQYPLPKMDN VAVHEFSAGA MENWGLVTYR VVDLLLDKDN STLDRIQRVA 300
  301 EVVQHELAHQ WFGNLVTMDW WEGLWLNEGF ATWMSWYSCN EFQPEWKVWE QYVTDTLQHA 360
  361 LSLDSLRSSH PIEVPVKKAD EINQIFDAIS YSKGASLLRM ISKWLGEETF IKGVSQYLNK 420
  421 FKYGNAKTED LWDALADASG KDVRSVMNIW TKKVGFPVIS VSEDGNGKIT FRQNRYLSTA 480
  481 DVKPDEDKTI YPVFLALKTK NGVDSSVVLS ERSKTIELED PTFFKVNSEQ SGIYITSYTD 540
  541 ERWAKLGQQA DLLSVEDRVG LVADVKTLSA SGYTSTTNFL NLVSKWNNEK SFVVWDQIIN 600
  601 SISSMKSTWL FEPKETQDAL DNFTKQLISG MTHHLGWEFK SSDSFSTQRL KVTMFGAACA 660
  661 ARDADVEKAA LKMFTDYCSG NKEAIPALIK PIVFNTVARV GGAENYEKVY KIYLDPISND 720
  721 EKLAALRSLG RFKEPKLLER TLGYLFDGTV LNQDIYIPMQ GMRAHQEGVE ALWNWVKKNW 780
  781 DELVKRLPPG LSMLGSVVTL GTSGFTSMQK IDEIKKFFAT KSTKGFDQSL AQSLDTITSK 840
  841 AQWG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] PSI-BLAST 245.228787 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    2 View Details [211..303] PSI-BLAST 245.228787 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    3 View Details [304..505] PSI-BLAST 245.228787 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    4 View Details [506..688] ORFEUS 11.01 Adaptin beta subunit N-terminal fragment
    5 View Details [689..844] ORFEUS 11.01 Adaptin beta subunit N-terminal fragment


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle