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Protein Overview: RRP8

General Information:
Name(s) found: RRP8 / YDR083W [SGD]
Description(s) found:
Found 8 descriptions.
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  • Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 383 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: methyltransferase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALFNVEGWS IKTKTVAFDN KTNKSSKDKK KNNRKNGKLT REQKLKEETE AELKEQVEDI  60
   61 PSEGSVAKDI PKKNQEKSDQ NETSKKRKHD EEAPLMQVKE NIEKPTKKQL TPLQQKMMAK 120
  121 LTGSRFRWIN EQLYTISSDE ALKLIKEQPQ LFDEYHDGFR SQVQAWPENP VDVFVDQIRY 180
  181 RCMKPVNAPG GLPGLKDSKE IVIADMGCGE AQLALEINNF FKNYNKKAKK YLKRRHKVHS 240
  241 FDLKKANERI TVADIRNVPL PDESCTIVVF CLALMGTNFL DFIKEAYRIL APRGELWIAE 300
  301 IKSRFSDGKG NEFVDALKLM GFFHKKTFDE NKMFTRFEFF KPPAEIIEER RQKLERRQKF 360
  361 IEVETEKEEL EKKRRKIAEE NGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] deduced N/A No confident structure predictions are available.
    2 View Details [126..383] PSI-BLAST 17.69897 CmaA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.15840198589582 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.08059259177729 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.99781997782052 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.89157295612945 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  2.57273894921779 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  2.26670816231281 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.55242772787972 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  1.21404153202137 bayes_pls_golite062009
  • transferase activity
    		•  1.07321114919891 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.03293084629981 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.954020631547781 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.742142092552002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • rRNA (uridine-2'-O-)-methyltransferase activity
    		•  0.15443733645953 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle