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Protein Overview: PKP2

General Information:
Name(s) found: PKP2 / YGL059W [SGD]
Description(s) found:
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  • gi|97537659|sp|P53170.2|YGF9_YEAST RecName: Full=Probable protein kinase YGL059W [NCBI NR]
  • gi|27808706|ref|NP_011456.2| Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Ygl059wp [Saccharomyces cerevisiae] [NCBI NR]
  • Probable protein kinase YGL059W OS=Saccharomyces cerevisiae GN=YGL059W PE=1 SV=2 [Swiss-Prot]
  • Protein of unknown function localised to cytoplasm and mitochondria [mips]
  • Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p [SGD]
  • Chr VII from 392226-393701 [yeastorf4.fasta]
  • YGL059W SGDID:S0003027, Chr VII from 392226-393701, Uncharacterized ORF [yeastflysequest.fasta]
  • YGL059W SGDID:S0003027, Chr VII from 392228-393703, Uncharacterized ORF [10112005cervSGD.fasta]
  • Ygl059wp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • YGL059W SGDID:S000003027, Chr VII from 392228-393703, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PKP2 SGDID:S000003027, Chr VII from 392228-393703, Verified ORF, "Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinas [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Probable protein kinase YGL059W [nr-271106-contam.fasta]
  • hypothetical protein; Ygl059wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PKP2 SGDID:S000003027, Chr VII from 392228-393703, Verified ORF, "Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYQINCIR YRHFLRTSNI SQIPDFTKYC IGPVNEELAP YIMETMKAYP SNSEYINPQH  60
   61 YYHNRTVLVE NYLKRSPNPV SLTQLAQYYD DSTKLTRTKI INSGKFVKEE LVIRIAHKLN 120
  121 QLQQLPFNVV NNFHFVQVYE SYYNIFESFR KYPTIRTLED ASQFADFIKN MLEGFNTLNL 180
  181 PHLIMGALEC TILDLYPREK MDQLLSDLLR ARISRRLIVE EHVVYTANYT SGKEENTLVL 240
  241 GDIFQECSAK KYLLEASEES QKFIQDMYFK DIPMPEFIIE GDTQLSFYFL PTHLKYLLGE 300
  301 ILRNTYEATM KHYIRKGLEK PEPIIVTVVS NDESYLFRIS DKAGGVLHDD ENLWSFGKSK 360
  361 ERAQESLNNF HKLPGLQTVS IYDEVHSHTK YNSKLKSLQS ITLKPYMHTS LEPMSYPSII 420
  421 NGHIKYETPL IELLKRSFRY KLGIGLAMCK VYAEYWNGDL SLHSMPGYGT DVVLKLGNLM 480
  481 KHTKKLQLDK V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPT3 PKP2 1 Unpublished Fields Lab Data
    View Screen RAD51 PKP2 1 Unpublished Fields Lab Data
    View Screen UBC7 PKP2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PKP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..491] PSI-BLAST 58.0 Pyruvate dehydrogenase kinase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle