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Protein Overview: SCD6

General Information:
Name(s) found: SCD6 / YPR129W [SGD]
Description(s) found:
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  • gi|939714|gb|AAA74093.1| Scd6p [NCBI NR]
  • gi|6325386|ref|NP_015454.1| Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin; Scd6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013919|gb|AAT93253.1| YPR129W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59743 SCD6 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1173375|sp|P45978.1|SCD6_YEAST RecName: Full=Protein SCD6 [NCBI NR]
  • gi|1066486|gb|AAB68271.1| Scd6p: Multicopy suppressor of clathrin deficiency [Saccharomyces cerevisiae] [NCBI NR]
  • Protein SCD6 OS=Saccharomyces cerevisiae GN=SCD6 PE=1 SV=1 [Swiss-Prot]
  • SCD6 Suppressor of clathrin deficiency [mips]
  • Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin [SGD]
  • (P45978) SCD6 protein [4932.FASTACCERV.txt]
  • Chr XVI from 792681-793730 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 792682-793731 [yeastorf3.fasta]
  • SCD6, Chr XVI from 792682-793731 [yeast_orfs2]
  • SCD6 SGDID:S0006333, Chr XVI from 792681-793730, Verified ORF [yeastflysequest.fasta]
  • SCD6 SGDID:S0006333, Chr XVI from 792683-793732, Verified ORF [10112005cervSGD.fasta]
  • Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin [Saccharomyces cerevisiae]gi|1066486|gb|AAB68271.1| Scd6p: Multicopy suppressor [nrdb_11152004_Chlamydomonas]
  • SCD6 SGDID:S000006333, Chr XVI from 792683-793732, Verified ORF, "Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Protein SCD6 [nr-271106-contam.fasta]
  • Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin; Scd6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Scd6p [nr-271106-contam.fasta]
  • YPR129W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Scd6p: Multicopy suppressor of clathrin deficiency [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Protein SCD6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCD6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SCD6 SGDID:S000006333, Chr XVI from 792687-793736, Genome Release 64-1-1, Verified ORF, "Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1" [yeast-030211-contam.fasta]
  • SCD6 SGDID:S000006333, Chr XVI from 792687-793736, Genome Release 64-2-1, Verified ORF, "Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress" [20141208_orf_trans.fasta]
  • YPR129W SGDID:S000006333, Chr XVI from 792687-793736, Genome Release 64-1-1, Verified ORF, "Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 349 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: RNA metabolic process [ISSLink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQYIGKTIS LISVTDNRYV GLLEDIDSEK GTVTLKEVRC FGTEGRKNWG PEEIYPNPTV  60
   61 YNSVKFNGSE VKDLSILDAN INDIQPVVPQ MMPPASQFPP QQAQSPPQAQ AQAHVQTNPQ 120
  121 VPKPESNVPA AVAGYGVYTP TSTETATASM NDKSTPQDTN VNSQSRERGK NGENEPKYQR 180
  181 NKNRSSNRPP QSNRNFKVDI PNEDFDFQSN NAKFTKGDST DVEKEKELES AVHKQDESDE 240
  241 QFYNKKSSFF DTISTSTETN TNMRWQEEKM LNVDTFGQAS ARPRFHSRGL GRGRGNYRGN 300
  301 RGNRGRGGQR GNYQNRNNYQ NDSGAYQNQN DSYSRPANQF SQPPSNVEF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EUG1 SCD6 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SCD6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] MSA 11.046997 View MSA. No confident structure predictions are available.
    2 View Details [190..349] MSA 1.038996 View MSA. No confident structure predictions are available.
    3 View Details [199..349] MSA 4.047991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.51705668632443 bayes_pls_golite062009
  • binding
    		•  1.99976233340317 bayes_pls_golite062009
    		• 1.84806098577575 bayes_pls_golite062009
  • RNA binding
    		•  1.49949321414131 bayes_pls_golite062009
  • protein binding
    		•  0.418315253537627 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle