Protein Overview: MRL1

General Information:
Name(s) found:	MRL1 / YPR079W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74676424\|sp\|Q06815.1\|MRL1_YEAST RecName: Full=Mannose 6-phosphate receptor-like protein 1; Flags: Precursor [NCBI NR] gi\|6325336\|ref\|NP_015404.1\| Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; Mrl1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S69065 probable membrane protein YPR079w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1230685\|gb\|AAB68128.1\| Ypr079wp [Saccharomyces cerevisiae] [NCBI NR] Mannose 6-phosphate receptor-like protein 1 OS=Saccharomyces cerevisiae GN=MRL1 PE=1 SV=1 [Swiss-Prot] MRL1 Mannose 6-phosphate Receptor Like [mips] Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases [SGD] >Q06815 (Q06815) Chromosome XVI COSMID 9513 [4932.FASTACCERV.txt] Chr XVI from 698865-700010 [hmr_yeast5_DM3-1_pombe.fasta] MRL1, Chr XVI from 698865-700010 [yeast_orfs2] MRL1 SGDID:S0006283, Chr XVI from 698865-700010, Verified ORF [yeastflysequest.fasta] MRL1 SGDID:S0006283, Chr XVI from 698867-700012, Verified ORF [10112005cervSGD.fasta] Ypr079wp [Saccharomyces cerevisiae]gi\|6325336\|ref\|NP_015404.1\| Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases [Saccharomyces cerevisiae]gi\|2133 [nrdb_11152004_Chlamydomonas] (Q06815) Ypr079wp [cerv4932.FASTAC] MRL1 SGDID:S000006283, Chr XVI from 698867-700012, Verified ORF, "Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; Mrl1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ypr079wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mannose 6-phosphate receptor-like protein 1 precursor [nr-271106-contam.fasta] [chemostatdb.fasta] Mannose 6-phosphate receptor-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRL1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MRL1 SGDID:S000006283, Chr XVI from 698869-700014, Genome Release 64-1-1, Verified ORF, "Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases" [yeast-030211-contam.fasta] MRL1 SGDID:S000006283, Chr XVI from 698869-700014, Genome Release 64-2-1, Verified ORF, "Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta] YPR079W SGDID:S000006283, Chr XVI from 698869-700014, Genome Release 64-1-1, Verified ORF, "Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	381 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] late endosome [IDA]
Biological Process:	vacuolar transport [IGI][ISS]
Molecular Function:	signal sequence binding [IGI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRSSLIYL SCVLIITIPI LLHVYNGPGL SHEANEHRAS HKQKRTLANP DKPKSENDED  60
   61 LFCAVTNPVT GSYIDLSQLS STPNKLREGQ KQISGNNKHE SSKTKWSVRG WGYDTNFTLG 120
  121 ICSSPVGEAE SQQLSNLTGA FYVDQLNENN LVSIGDFSTR PALVGGSTAK KLTLKYENGS 180
  181 MCPNGKDKKA TLLNFVCDKE IQSKAQISYI GNLHNCSYFF EVRSIHACPT SNKKNEVNVL 240
  241 GIFIGIFAIF FLVEFAGRRW IYAKLNRHLK NDDELHDISP SLNEQPHWDL IEDGSRWSKF 300
  301 FNGIIKTTRR FTKSLMRSLV RGRNSRQGGI RLRSSPSASS SSLANREFFR DMEAQNEIID 360
  361 SLDINSHTTE SDHPTLADNS V

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		MRL1 PIB2 VTH1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RGT2	MRL1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MRL1	Huh WK, et al. (2003)
View Data	MRL1 and SNF7	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..59]	deduced	N/A	No confident structure predictions are available.
2	View Details	[60..229]	PSI-BLAST	27.39794	Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
3	View Details	[230..381]	PSI-BLAST	24.0	Cation-independent mannose-6-phosphate receptor (MIR-receptor)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2