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Protein Overview: MSF1

General Information:
Name(s) found: MSF1 / YPR047W [SGD]
Description(s) found:
Found 11 descriptions.
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  • Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: translation [IMPLink to PubMed article]
    Molecular Function: phenylalanine-tRNA ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVTSMFLNR MMKTRTGLYR LYSTLKVPHV EINGIKYKTD PQTTNVTDSI IKLTDRSLHL  60
   61 KESHPVGILR DLIEKKLNSV DNTFKIFNNF KPVVTTMENF DSLGFPKDHP GRSKSDTYYI 120
  121 NETHLLRTHT SAHELECFQK IRNDSDNIKS GFLISADVYR RDEIDKTHYP VFHQMEGATI 180
  181 WKRTKADVGV KEPMYIEKIR EDIRQVENLL NKENVKITVD DDTIPLKENN PKQEYMSDLE 240
  241 VDLCSQHLKR SIELIVSEVF NKKISSMIKN KANNTPKELK VRWINAYFPW TAPSWEIEVW 300
  301 WQGEWLELCG CGLIRQDVLL RAGYKPSETI GWAFGLGLDR IAMLLFEIPD IRLLWSRDER 360
  361 FSRQFSKGLI TSFKPYSKHP GSFRDVAFWL PEDKPDIHQV HENDLMEIIR NIAGDLVESV 420
  421 KLVDSFTHPK TGRKSMCYRI NYQSMDRNLT NAEVNTLQDM VCSKLVKEYS VELR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..283] PSI-BLAST 106.221849 Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS
    2 View Details [284..366] Pfam 5.508638 tRNA synthetases class II core domain (F) No confident structure predictions are available.
    3 View Details [367..474] Pfam 48.05061 Ferredoxin-fold anticodon binding domain No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle