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Protein Overview: SRP72

General Information:
Name(s) found: SRP72 / YPL210C [SGD]
Description(s) found:
Found 12 descriptions.
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  • Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 646 amino acids

    Gene Ontology:
    Cellular Component: signal recognition particle, endoplasmic reticulum targeting [IDALink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [ICLink to PubMed article]
    protein targeting to ER [IPILink to PubMed article]
    Molecular Function: signal sequence binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKESKKMAKD NLTNLLSQLN IQLSQDEHSQ VEQTCVKLLD SGCENPADVF RRCLVAVIQQ  60
   61 DKYQKALHYL KKFKHIDDKY GRKFALEKLY IFYKLNMPDE FNTLYTAIIT DDLDTVLKKD 120
  121 IESLRGILHV RAQYCYKNGL YQEAFKIYQH LASHNEKDQD SQIELSCNER VPLSVATELM 180
  181 NRSPLVTPMD ESSYDLLFNE SFIMASVGKY DKAIELLEKA LQGATNEGYQ NDINTIKLQL 240
  241 SFVLQMVGKT AQSKEILKGL LQELKADSPF SLICQNNLNA FVDFSKYNTN FNLLLRELNV 300
  301 EKLNTFNLQT FTHEQWSNIQ RNVLFLRLFN NVKIHSQESL LSRTFDKYSK LVDNVTLESY 360
  361 KTQAKKLYHH TTKTILSGTD GSTIGILLLT IQLLIIEKEW ENAIRIGELF LNESWKSSFE 420
  421 KFNDSQAIVC YILFELYKIK GRNNSKSVLL KKLGSVRVQL SGKIQENIPF WKHVGFELLS 480
  481 MGNAKESKAL LREISNFSKG DADVLVDRVV SSDSLDIAQG IDLVRDIDID KLIQLGVKPL 540
  541 ESSAKRSKNT AVSKVQKRKV LELKKKRKIK RLEKFLQGRD TSKLPDPERW LPLRDRSTYR 600
  601 PKKKQQGAKQ TQGGAMNKKS EQALDISKKG KPTVNKKPKN KKKGRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] PSI-BLAST 19.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [140..249] PSI-BLAST 19.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [250..378] PSI-BLAST 10.09691 FKBP51, C-terminal domain; FKBP51, N-terminal domains
    4 View Details [379..580] MSA 13.751997 View MSA. No confident structure predictions are available.
    5 View Details [581..646] MSA 1.037993 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle