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Protein Overview: AFT2

General Information:
Name(s) found: AFT2 / YPL202C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 416 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IMPLink to PubMed article][ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    response to oxidative stress [IMPLink to PubMed article][ISSLink to PubMed article]
    positive regulation of transcription [IDALink to PubMed article]
    transcription initiation from RNA polymerase II promoter [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAKSMKSII SVPISVSKTG KMKLTASPDN LASMMSKDQN KLIHLDPVPS FEDRHEIKPW  60
   61 LQKIFYPQGI DIVIERSDSS KVTFKCRSVR SKVGLNPKSK GSSSRSHACP FRIRAAYSVR 120
  121 LQKWNVVVMN NIHSHELRFD LITKTDDYKK FKENLRQKND EKAIKTFDEL EYKASLNLPL 180
  181 VTPIISCDCG LTKEIEAFNN IFLPLSNPPL TSKKNLLKTN KNSVSKIKSR QMDNSKPRPR 240
  241 LKTKLDADLH DTGFLDNFKT RNSCVKIEKE DSLTNLNEID FTNMFCNDNF IQNYNQGLME 300
  301 LLTEPTPGPS SSSCILPSTP TRPLSQSKMD IALSESTTSS PNFMETDAPY GDEIIKVSKD 360
  361 TKSNAPTADT DIATNLGKER NENFGMLNYN YEALLHFNDE HFNELNSIDP ALISKY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data AFT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..227] deduced N/A No confident structure predictions are available.
    2 View Details [228..303] MSA 1.003985 View MSA. No confident structure predictions are available.
    3 View Details [304..416] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle