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Protein Overview: HEM4

General Information:
Name(s) found: HEM4 / YOR278W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 275 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: heme biosynthetic process [IMPLink to PubMed article]
    Molecular Function: uroporphyrinogen-III synthase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRKKVRVL LLKNKTVPID KYELECRSKA FEPIFVPLIK HTHVIQDFRN VLNTIPNYLN  60
   61 TINYIIITSQ RTVESLNEAI IPTLTSEQKA ALLSKTVYTV GPATANFIRR SGFINVKGGE 120
  121 DAGNGSILAD IIIDDLSTDI KACPPSELLF LVGEIRRDII PKKLHSKGIK VREVVTYKTE 180
  181 ELSDGFKRFI HAMKECDEDE VFSDWVVVFS PQGTKEITQY LGDSNRLPGS HLRVASIGPT 240
  241 TKKYLDDNDV TSDVVSPKPD PKSLLDAIEL YQRHK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..40]
    [180..275]    		 PSI-BLAST 165.228787 Uroporphyrinogen III synthase (U3S, HemD)
    2 View Details [41..179] PSI-BLAST 165.228787 Uroporphyrinogen III synthase (U3S, HemD)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • uroporphyrinogen-III synthase activity
    		•  3.6508024043308 bayes_pls_golite062009
  • catalytic activity
    		•  1.13824203225664 bayes_pls_golite062009
  • hydro-lyase activity
    		•  0.290711782955013 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle