Protein Overview: LIP5

General Information:
Name(s) found:	LIP5 / YOR196C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324770\|ref\|NP_014839.1\| Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase; Lip5p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S42159 lipoic acid synthase (EC 2.8.1.-) precursor [validated] - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|45269982\|gb\|AAS56372.1\| YOR196C [Saccharomyces cerevisiae] [NCBI NR] gi\|417254\|sp\|P32875.1\|LIP5_YEAST RecName: Full=Lipoyl synthase, mitochondrial; AltName: Full=Lipoic acid synthase; AltName: Full=Lipoate synthase; Short=Lip-syn; Short=LS; Flags: Precursor [NCBI NR] gi\|1420467\|emb\|CAA99409.1\| LIP5 [Saccharomyces cerevisiae] [NCBI NR] Lipoyl synthase, mitochondrial OS=Saccharomyces cerevisiae GN=LIP5 PE=1 SV=1 [Swiss-Prot] LIP5 Lipoic acid synthase [mips] Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase [SGD] (P32875) Lipoic acid synthetase, mitochondrial precursor (Lip-syn) (Lipoate synthase) [4932.FASTACCERV.txt] Chr XV from 716837-715593, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 715592-716836, reverse complement [yeastorf3.fasta] Chr XV from 715593-716837, reverse complement [yeastorf4.fasta] LIP5, Chr XV from 715592-716836, reverse complement [yeast_orfs2] LIP5 SGDID:S0005722, Chr XV from 716837-715593, reverse complement, Verified ORF [yeastflysequest.fasta] Lip5p [Saccharomyces cerevisiae]gi\|1420467\|emb\|CAA99409.1\| LIP5 [Saccharomyces cerevisiae]gi\|45269982\|gb\|AAS56372.1\| YOR196C [Saccharomyces cerevisiae]gi\|630264\|pir\|\|S42159 lipoic acid synthase (EC 2.8.1.-) precursor [validated] - yeast (Saccharomyces [nrdb_11152004_Chlamydomonas] LIP5 SGDID:S000005722, Chr XV from 716837-715593, reverse complement, Verified ORF, "Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] LIP5 SGDID:S000005722, Chr XV from 716838-715594, reverse complement, Verified ORF, "Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase" [yeast-contam.fasta] YOR196C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase; Lip5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] LIP5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Lipoic acid synthetase, mitochondrial precursor (Lip-syn) (Lipoate synthase) [nr-271106-contam.fasta] [chemostatdb.fasta] LIP5 SGDID:S000005722, Chr XV from 716837-715593, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase" [yeast-030211-contam.fasta] LIP5 SGDID:S000005722, Chr XV from 716837-715593, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase" [20141208_orf_trans.fasta] YOR196C SGDID:S000005722, Chr XV from 716837-715593, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	414 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ]
Biological Process:	lipoic acid biosynthetic process [IMP]
Molecular Function:	lipoic acid synthase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRRSVGVLF VGRNTRWISS TIRCGTSATR PIRSNALNTD SDNASVRVPV GNSTEVENAT  60
   61 SQLTGTSGKR RKGNRKRITE FKDALNLGPS FADFVSGKAS KMILDPLEKA RQNTEEAKKL 120
  121 PRWLKVPIPK GTNYHKLKGD VKELGLSTVC EEARCPNIGE CWGGKDKSKA TATIMLLGDT 180
  181 CTRGCRFCSV KTNRTPSKPD PMEPENTAEA IKRWGLGYVV LTTVDRDDLV DGGANHLAET 240
  241 VRKIKQKAPN TLVETLSGDF RGDLKMVDIM AQCGLDVYAH NLETVESLTP HVRDRRATYR 300
  301 QSLSVLERAK ATVPSLITKT SIMLGLGETD EQITQTLKDL RNIQCDVVTF GQYMRPTKRH 360
  361 MKVVEYVKPE KFDYWKERAL EMGFLYCASG PLVRSSYKAG EAFIENVLKK RNMK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ASC1 LIP5 TRK1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	LIP5	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..177]	MSA	1.689988	View MSA. No confident structure predictions are available.
2	View Details	[178..414]	ORFEUS	8.19	Deoxyribose-phosphate aldolase DeoC

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: LIP5

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: