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Protein Overview: CDC21

General Information:
Name(s) found: CDC21 / YOR074C [SGD]
Description(s) found:
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  • ref|NP_014717.1| Cdc21p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||YXBYT thymidylate synthase (EC 2.1.1.45) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420229|emb|CAA99267.1| CDC21 [Saccharomyces cerevisiae] [NCBI NR]
  • Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S [SGD]
  • Chr XV from 467590-467491,467355-466676, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 466676-466775,466911-467590, reverse complement [yeastorf3.fasta]
  • CDC21, Chr XV from 466676-466775,466911-467590, reverse complement [yeast_orfs2]
  • CDC21 SGDID:S0005600, Chr XV from 467590-467491,467355-466676, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Cdc21p [Saccharomyces cerevisiae]gi|1420229|emb|CAA99267.1| CDC21 [Saccharomyces cerevisiae]gi|2144395|pir||YXBYT thymidylate synthase (EC 2.1.1.45) - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • CDC21 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 259 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: DNA-dependent DNA replication [TAS]
    dTMP biosynthetic process [TAS]
    Molecular Function: thymidylate synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMDGKNKEE EQYLDLCKRI IDEGEFRPDR TGTDANLLSE QGVKIWDGNG SREYLDKMGF  60
   61 KDRKVGDLGP VYGFQWRHFG AKYKTCDDDY TGQGIDQLKQ VIHKLKTNPY DRRIIMSAWN 120
  121 PADFDKMALP PCHIFSQFYV SFPKEGEGSG KPRLSCLLYQ RSCDMGLGVP FNIASYALLT 180
  181 RMIAKVVDME PGEFIHTLGD AHVYKDHIDA LKEQITRNPR PFPKLKIKRD VKDIDDFKLT 240
  241 DFEIEDYNPH PRIQMKMSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NOG1 CDC21 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] PSI-BLAST 104.0 Thymidylate synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
    		•  6.29181090719132 bayes_pls_golite062009
  • thymidylate synthase activity
    		•  6.13538715987923 bayes_pls_golite062009
  • catalytic activity
    		•  1.73427871128495 bayes_pls_golite062009
  • binding
    		•  1.29787993009039 bayes_pls_golite062009
  • transferase activity
    		•  1.02276089025842 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.927096828883487 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.91282507161672 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle