Protein Overview: ALR1

General Information:
Name(s) found:	ALR1 / YOL130W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324442\|ref\|NP_014511.1\| Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Alr1p [Saccharomyces cerevisiae] [NCBI NR] gi\|51012975\|gb\|AAT92781.1\| YOL130W [Saccharomyces cerevisiae] [NCBI NR] gi\|2498122\|sp\|Q08269.1\|ALR1_YEAST RecName: Full=Magnesium transporter ALR1; AltName: Full=Aluminum resistance protein 1 [NCBI NR] pir\|\|S66827 aluminium resistance protein ALR1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420017\|emb\|CAA99150.1\| ALR1 [Saccharomyces cerevisiae] [NCBI NR] Magnesium transporter ALR1 OS=Saccharomyces cerevisiae GN=ALR1 PE=1 SV=1 [Swiss-Prot] ALR1 Transporter of magnesium and other divalent cations [mips] Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions [SGD] (Q08269) Aluminum resistance protein 1 [4932.FASTACCERV.txt] Chr XV from 74399-76978 [hmr_yeast5_DM3-1_pombe.fasta] ALR1, Chr XV from 74399-76978 [yeast_orfs2] ALR1 SGDID:S0005490, Chr XV from 74399-76978, Verified ORF [yeastflysequest.fasta] Alr1p [Saccharomyces cerevisiae]gi\|51012975\|gb\|AAT92781.1\| YOL130W [Saccharomyces cerevisiae]gi\|1420017\|emb\|CAA99150.1\| ALR1 [Saccharomyces cerevisiae]gi\|2132848\|pir\|\|S66827 aluminium resistance protein ALR1 - yeast (Saccharomyces cerevisiae)gi\|249812 [nrdb_11152004_Chlamydomonas] (Q08269) Magnesium transporter ALR1 (Aluminum resistance protein 1) [cerv4932.FASTAC] ALR1 SGDID:S000005490, Chr XV from 74399-76978, Verified ORF, "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ALR1 SGDID:S000005490, Chr XV from 74400-76979, Verified ORF, "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions" [yeast-contam.fasta] Magnesium transporter ALR1 (Aluminum resistance protein 1) [nr-271106-contam.fasta] Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Alr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YOL130W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ALR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Magnesium transporter ALR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ALR1 SGDID:S000005490, Chr XV from 74400-76979, Genome Release 64-1-1, Verified ORF, "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions" [yeast-030211-contam.fasta] ALR1 SGDID:S000005490, Chr XV from 74400-76979, Genome Release 64-2-1, Verified ORF, "Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions" [20141208_orf_trans.fasta] YOL130W SGDID:S000005490, Chr XV from 74400-76979, Genome Release 64-1-1, Verified ORF, "Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	859 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IMP]
Biological Process:	di-, tri-valent inorganic cation transport [IMP][ISS] magnesium ion transport [IDA]
Molecular Function:	di-, tri-valent inorganic cation transmembrane transporter activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSSSSES SPNLSRSNSL ANTMVSMKTE DHTGLYDHRQ HPDSLPVRHQ PPTLKNKEIA  60
   61 KSTKPSIPKE QKSATRYNSH VDVGSVPSRG RMDFEDEGQG MDETVAHHQL RASAILTSNA 120
  121 RPSRLAHSMP HQRQLYVESN IHTPPKDVGV KRDYTMSSST ASSGNKSKLS ASSSASPITK 180
  181 VRKSSLVSPV LEIPHESKSD THSKLAKPKK RTYSTTSAHS SINPAVLLTK STSQKSDADD 240
  241 DTLERKPVRM NTRASFDSDV SQASRDSQET EEDVCFPMPP QLHTRVNGID FDELEEYAQF 300
  301 ANAEKSQFLA SLQVPNEQKY SNVSQDIGFT SSTSTSGSSA ALKYTPRVSQ TGEKSESTNE 360
  361 TEIHEKKEDE HEKIKPSLHP GISFGKNKVE GEENENIPSN DPAYCSYQGT DFQIPNRFSF 420
  421 FCSESDETVH ASDIPSLVSE GQTFYELFRG GEPTWWLDCS CPTDDEMRCI AKAFGIHPLT 480
  481 AEDIRMQETR EKVELFKSYY FVCFHTFEND KESEDFLEPI NVYIVVCRSG VLTFHFGPIS 540
  541 HCANVRRRVR QLRDYVNVNS DWLCYALIDD ITDSFAPVIQ SIEYEADAIE DSVFMARDMD 600
  601 FAAMLQRIGE SRRKTMTLMR LLSGKADVIK MFAKRCQDEA NGIGPALTSQ INIANLQARQ 660
  661 DNASHIKNNS STTVPNNYAP TTSQPRGDIA LYLGDIQDHL LTMFQNLLAY EKIFSRSHTN 720
  721 YLAQLQVESF NSNNKVTEML GKVTMIGTML VPLNVITGLF GMNVKVPGEN SSIAWWFGIL 780
  781 GVLLLLAVLG WFLASYWIKR IDPPATLNEA AESGAKSVIS SFLPKRNKRF NDRSKNINVR 840
  841 AGPSNKSVAS LPSRYSRYD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ASF1	3829 - low filter	Green EM, et al (2005)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NAF1	ALR1	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ALR1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..365]	deduced	N/A	No confident structure predictions are available.
2	View Details	[366..554]	MSA	1.085986	View MSA. No confident structure predictions are available.
3	View Details	[555..677]	ORFEUS	7.71	alpha-actinin
4	View Details	[678..859]	ORFEUS	7.71	alpha-actinin

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2