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Protein Overview: THI20

General Information:
Name(s) found: THI20 / YOL055C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 551 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: thiamin catabolic process [IDALink to PubMed article]
    thiamin biosynthetic process [IEPLink to PubMed article][IGILink to PubMed article]
    Molecular Function: hydroxymethylpyrimidine kinase activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    thiaminase activity [IDALink to PubMed article]
    phosphomethylpyrimidine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYSTVSINT PPPYLTLACN EKLPTVLSIA GTDPSGGAGI EADVKTITAH RCYAMTCITA  60
   61 LNAQTPVKVY SINNTPKEVV FQTLESNLKD MKCNVIKTGM LTAAAIEVLH EKLLQLGENR 120
  121 PKLVVDPVLV ATSGSSLAGK DIVSLITEKV APFADILTPN IPECYKLLGE ERKVNGLQDI 180
  181 FQIAKDLAKI TKCSNILVKG GHIPWNDEKE KYITDVLFLG AEQKFIIFKG NFVNTTHTHG 240
  241 TGCTLASAIA SNLARGYSLP QSVYGGIEYV QNAVAIGCDV TKETVKDNGP INHVYAVEIP 300
  301 LEKMLSDECF TASDVIPKKP LKSAADKIPG GNFYEYLINH PKVKPHWDSY INHEFVKKVA 360
  361 DGTLERKKFQ FFIEQDYAYL VDYARVHCIA GSKAPCLEDM EKELVIVGGV RTEMGQHEKR 420
  421 LKEVFGVKDP DYFQKIKRGP ALRAYSRYFN DVSRRGNWQE LVASLTPCLM GYGEALTKMK 480
  481 GKVTAPEGSV YHEWCETYAS SWYREAMDEG EKLLNHILET YPPEQLDTLV TIYAEVCELE 540
  541 TNFWTAALEY E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data THI20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..316] PSI-BLAST 351.28043 No description for 1lljA_ was found.
    2 View Details [317..551] ORFEUS 8.81 Heme oxygenase-1 (HO-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.14277879659132 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle