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Protein Overview: GSH2

General Information:
Name(s) found: GSH2 / YOL049W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: response to heat [IEPLink to PubMed article]
    glutathione biosynthetic process [IMPLink to PubMed article]
    Molecular Function: glutathione synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHYPPSKDQ LNELIQEVNQ WAITNGLSMY PPKFEENPSN ASVSPVTIYP TPIPRKCFDE  60
   61 AVQIQPVFNE LYARITQDMA QPDSYLHKTT EALALSDSEF TGKLWSLYLA TLKSAQYKKQ 120
  121 NFRLGIFRSD YLIDKKKGTE QIKQVEFNTV SVSFAGLSEK VDRLHSYLNR ANKYDPKGPI 180
  181 YNDQNMVISD SGYLLSKALA KAVESYKSQQ SSSTTSDPIV AFIVQRNERN VFDQKVLELN 240
  241 LLEKFGTKSV RLTFDDVNDK LFIDDKTGKL FIRDTEQEIA VVYYRTGYTT TDYTSEKDWE 300
  301 ARLFLEKSFA IKAPDLLTQL SGSKKIQQLL TDEGVLGKYI SDAEKKSSLL KTFVKIYPLD 360
  361 DTKLGREGKR LALSEPSKYV LKPQREGGGN NVYKENIPNF LKGIEERHWD AYILMELIEP 420
  421 ELNENNIILR DNKSYNEPII SELGIYGCVL FNDEQVLSNE FSGSLLRSKF NTSNEGGVAA 480
  481 GFGCLDSIIL Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GSH2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..356]
    [416..491]    		 PSI-BLAST 852.9794 Eukaryotic glutathione synthetase, substrate-binding domain; Eukaryotic glutathione synthetase ATP-binding domain
    2 View Details [357..415] PSI-BLAST 852.9794 Eukaryotic glutathione synthetase, substrate-binding domain; Eukaryotic glutathione synthetase ATP-binding domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle