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Protein Overview: AIF1

General Information:
Name(s) found: AIF1 / YNR074C [SGD]
Description(s) found:
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  • gi|805057|emb|CAA60487.1| N3815 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6324402|ref|NP_014472.1| Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase; Aif1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1730701|sp|P52923.1|AIF1_YEAST RecName: Full=Apoptosis-inducing factor 1; AltName: Full=Cercosporin and photosensitizer-detoxification protein 1 [NCBI NR]
  • gi|1302612|emb|CAA96357.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S54056 probable membrane protein YNR074c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (P52923) Uncharacterized protein YNR074C [Swiss-Prot]
  • Apoptosis-inducing factor 1 OS=Saccharomyces cerevisiae GN=AIF1 PE=1 SV=1 [Swiss-Prot]
  • AIF1 Apoptosis-Inducing Factor [mips]
  • Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase [SGD]
  • (P52923) Hypothetical 41.3 kDa protein in HXT17-COS10 intergenic region [4932.FASTACCERV.txt]
  • Chr XIV from 778733-777597, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XIV from 777597-778733, reverse complement [yeastorf3.fasta]
  • YNR074C, Chr XIV from 777597-778733, reverse complement [yeast_orfs2]
  • YNR074C SGDID:S0005357, Chr XIV from 778735-777599, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • YNR074C SGDID:S0005357, Chr XIV from 778736-777600, reverse complement, Uncharacterized ORF [10112005cervSGD.fasta]
  • Ynr074cp [Saccharomyces cerevisiae]gi|805057|emb|CAA60487.1| N3815 [Saccharomyces cerevisiae]gi|1302612|emb|CAA96357.1| unnamed protein product [Saccharomyces cerevisiae]gi|1078141|pir||S54056 probable membrane protein YNR074c - yeast (Saccharomyces ce [nrdb_11152004_Chlamydomonas]
  • AIF1 SGDID:S000005357, Chr XIV from 778738-777602, reverse complement, Verified ORF, "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • N3815 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase; Aif1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Uncharacterized protein YNR074C [nr-271106-contam.fasta]
  • AIF1 SGDID:S000005357, Chr XIV from 778739-777603, reverse complement, Verified ORF, "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • Apoptosis-inducing factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AIF1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • AIF1 SGDID:S000005357, Chr XIV from 778738-777602, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase" [yeast-030211-contam.fasta]
  • AIF1 SGDID:S000005357, Chr XIV from 778738-777602, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase" [20141208_orf_trans.fasta]
  • YNR074C SGDID:S000005357, Chr XIV from 778738-777602, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 378 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    plasma membrane [ISSLink to PubMed article]
    Biological Process: positive regulation of apoptosis [IMPLink to PubMed article]
    response to singlet oxygen [IMPLink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [ISS]
    oxidoreductase activity [IEA]
    FAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTINTKNIVV VGAGVFGVSV ANHLYRELGG TYAIKLVTAS NYVYFLPSAV RLTVSKDYTK  60
   61 SILPLKNVLD SGIEVIKDTA ASFDDKEVVL GSDRAIKFDI LVLATGSKWA DPIGSTYTFG 120
  121 DNYKEYFERE ASRISDADHI LFLGGGFVNC ELAGELLFKY LEEIRSGKKR ISIIHNSDKL 180
  181 LPDSGLYNDT LRKNVTDYLS KNGITLYLNT VGASLDTSPK RIFLGEGSSK YIDADLIYRG 240
  241 VGISPNVPVN SISDLCDKKG FIQVEKNFRV KAVEAGNVFA IGDVTNFRYH GLVKRDNWVD 300
  301 VLTRNVISSL QEGTEASLVD ADCLETGHAP SGVSLGPNAG FGQFPLPLLG TINIPSFLIS 360
  361 RAKSKNLFSD KMEPLFKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AIF1 NDI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..45]
    [58..109]
    [243..378]    		 PSI-BLAST 118.512579 Trypanothione reductase
    2 View Details [46..57]
    [110..242]    		 PSI-BLAST 118.512579 Trypanothione reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.37477730756688 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.17769237742078 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.86780802427711 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.6431755180135 bayes_pls_golite062009
  • binding
    		•  1.4227698123368 bayes_pls_golite062009
  • protein binding
    		•  1.16738144711505 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  1.11021120187216 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.48971304115416 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  0.0160065137614933 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle