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Protein Overview: BIO4

General Information:
Name(s) found: BIO4 / YNR057C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 237 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISSLink to PubMed article]
    Biological Process: biotin biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: dethiobiotin synthase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSKSQQQEQ QPIVFVTGTD TDVGKTFVST LLVHKWKAAY WKPVQTGIES DQGDSETLKN  60
   61 FKIAASTWQP PIFTPTYALQ KPLSPLQAME YEPNVDIRLL DFVVPEEWSA ENPLVVEGAG 120
  121 GVCVPITRKL EITTDLIKHL IETSGHPVYV VVVARSGLGT LNHTLLTWNH LCDNGLRSHL 180
  181 FGVILNGEPN EGNVQALKKF GVNIMAQVAQ CTTAHDQDME LHELPSVESL MTQQDVE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] PSI-BLAST 1396.69897 No description for 1m3tA_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle