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Protein Overview: TRF5

General Information:
Name(s) found: TRF5 / YNL299W [SGD]
Description(s) found:
Found 16 descriptions.
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  • Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 625 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: ncRNA polyadenylation [IGILink to PubMed article]
    mitotic sister chromatid cohesion [IGILink to PubMed article]
    rRNA catabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    snRNA catabolic process [IGILink to PubMed article]
    snoRNA catabolic process [IGILink to PubMed article]
    ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [IGILink to PubMed article]
    Molecular Function: DNA-directed DNA polymerase activity [IDALink to PubMed article][ISSLink to PubMed article]
    polynucleotide adenylyltransferase activity [IDALink to PubMed articleLink to PubMed article][IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRLKAKYSP TKGKRKEDKH TKRMRKSSFT RTQKMLEVFN DNRSHFNKYE SLAIDVEDDD  60
   61 TFGNLVLMEN DKSDVDIPVI EEVTSSEDEQ RAESSKRNNS LEDNQDFIAF SDSSEDETEQ 120
  121 IKEDDDERSS FLLTDEHEVS KLTSQQSLNT ESACNVEYPW IRNHCHSKQR RIADWLTSEI 180
  181 KDFVHYISPS KNEIKCRNRT IDKLRRAVKE LWSDADLHVF GSFATDLYLP GSDIDCVVNS 240
  241 RNRDKEDRNY IYELARHLKN KGLAIRMEVI VKTRVPIIKF IEPQSQLHID VSFERTNGLE 300
  301 AAKLIREWLR DSPGLRELVL IIKQFLHSRR LNNVHTGGLG GFTVICLVYS FLNMHPRIKS 360
  361 NDIDVLDNLG VLLIDFFELY GKNFGYDDVA ISISDGYASY IPKSCWRTLE PSRSKFSLAI 420
  421 QDPGDPNNNI SRGSFNMKDI KKAFAGAFEL LVNKCWELNS ATFKDRVGKS ILGNVIKYRG 480
  481 QKRDFNDERD LVQNKAIIEN ERYHKRRTRI VQEDLFINDT EDLPVEEIYK LDEPAKKKQK 540
  541 AKKDKREGEI KKSAIPSPPP DFGVSRSKLK RKVKKTDQGS LLHQNNLSID DLMGLSENDQ 600
  601 ESDQDQKGRD TLRDKMRNHH WKLRQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] deduced N/A No confident structure predictions are available.
    2 View Details [123..189]
    [301..502]    		 PSI-BLAST 65.09691 Poly(A) polymerase, middle domain; Poly(A) polymerase N-terminal, catalytic domain; Poly(A) polymerase, C-terminal domain
    3 View Details [190..300] PSI-BLAST 65.09691 Poly(A) polymerase, middle domain; Poly(A) polymerase N-terminal, catalytic domain; Poly(A) polymerase, C-terminal domain
    4 View Details [503..625] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleotidyltransferase activity
    		•  6.98311287327254 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  5.66611091580726 bayes_pls_golite062009
  • transferase activity
    		•  4.39508042323068 bayes_pls_golite062009
  • RNA binding
    		•  3.35578898341041 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.53528619920768 bayes_pls_golite062009
  • DNA binding
    		•  1.92558226050462 bayes_pls_golite062009
  • polynucleotide adenylyltransferase activity
    		•  1.54779952898232 bayes_pls_golite062009
  • binding
    		•  1.48092751553298 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.21103668998054 bayes_pls_golite062009
  • catalytic activity
    		•  0.75232920999699 bayes_pls_golite062009
  • tubulin binding
    		•  0.646904711098669 bayes_pls_golite062009
  • microtubule binding
    		•  0.546269140865214 bayes_pls_golite062009
  • transcription factor binding
    		•  0.303837517417996 bayes_pls_golite062009
  • protein binding
    		•  0.117945573723438 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.49

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle