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Protein Overview: FOL1

General Information:
Name(s) found: FOL1 / YNL256W [SGD]
Description(s) found:
Found 12 descriptions.
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  • Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 864 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mitochondrial envelope [IDALink to PubMed article]
    Biological Process: folic acid and derivative biosynthetic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [IDALink to PubMed article][ISSLink to PubMed article]
    dihydroneopterin aldolase activity [IDALink to PubMed article][ISSLink to PubMed article]
    dihydropteroate synthase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINCKVIENR RTRFFPLVNA KLVKVIASSL INKFQSLPLA MSKLFSTVNS ARHSVPLGGM  60
   61 RDYVHIKKLE MNTVLGPDSW NQLMPQKCLL SLDMGTDFSK SAATDDLKYS LNYAVISRDL 120
  121 TNFVSKKKNW GSVSNLAKSV SQFVMDKYSG VECLNLEVQA DTTHIRSDHI SCIIQQERGN 180
  181 PESQEFDVVR ISELKMLTLI GVFTFERLKK QYVTLDIKLP WPKKAELPPP VQSIIDNVVK 240
  241 FVEESNFKTV EALVESVSAV IAHNEYFQKF PDSPLVVKVL KLNAITATEG VGVSCIREPR 300
  301 EIAMVNIPYL SSIHESSDIK FQLSSSQNTP IEGKNTWKRA FLAFGSNIGD RFKHIQMALQ 360
  361 LLSREKTVKL RNISSIFESE PMYFKDQTPF MNGCVEVETL LTPSELLKLC KKIEYEELQR 420
  421 VKHFDNGPRT IDLDIVMFLN SAGEDIIVNE PDLNIPHPRM LERTFVLEPL CELISPVHLH 480
  481 PVTAEPIVDH LKQLYDKQHD EDTLWKLVPL PYRSGVEPRF LKFKTATKLD EFTGETNRIT 540
  541 VSPTYIMAIF NATPDSFSDG GEHFADIESQ LNDIIKLCKD ALYLHESVII DVGGCSTRPN 600
  601 SIQASEEEEI RRSIPLIKAI RESTELPQDK VILSIDTYRS NVAKEAIKVG VDIINDISGG 660
  661 LFDSNMFAVI AENPEICYIL SHTRGDISTM NRLAHYENFA LGDSIQQEFV HNTDIQQLDD 720
  721 LKDKTVLIRN VGQEIGERYI KAIDNGVKRW QILIDPGLGF AKTWKQNLQI IRHIPILKNY 780
  781 SFTMNSNNSQ VYVNLRNMPV LLGPSRKKFI GHITKDVDAK QRDFATGAVV ASCIGFGSDM 840
  841 VRVHDVKNCS KSIKLADAIY KGLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 34.154902 7,8-dihydroneopterin aldolase
    2 View Details [221..318] deduced N/A No confident structure predictions are available.
    3 View Details [319..514] PSI-BLAST 202.751666 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
    4 View Details [515..680]
    [740..752]    		 PSI-BLAST 361.594777 Dihydropteroate synthetase
    5 View Details [681..739]
    [753..864]    		 PSI-BLAST 361.594777 Dihydropteroate synthetase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle