YRC Public Data Repository - Protein Structure Prediction

Protein:	FOL1
Organism:	Saccharomyces cerevisiae
Length:	864 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOL1.

Description	E-value	Query Range	Subject Range
FOL1_PNECA - Folic acid synthesis protein fol1 OS=Pneumocystis carinii GN=fol1 PE=1 SV=1	0.0	[53..861]	[30..737]
SPBC1734.03 - dihydropteroatesynthase /2-amino-4-hydroxy-6-hydroxymethyldihydropteridinediphosphokinase /dihydroneop... FOL1_SCHPO - Folic acid synthesis protein fol1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fol1 PE=...	0.0	[60..860]	[4..683]
FOLM_ARATH - Folate synthesis bifunctional protein, mitochondrial OS=Arabidopsis thaliana GN=MitHPPK/DHPS PE=2 SV...	0.0	[302..861]	[52..548]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[303..861]	[7..505]
gi\|157073011, gi... - gi\|164429281\|ref\|XP_957887.2\| hypothetical protein NCU09930 [Neurospora crassa OR74A], gi\|157073011\|... gi\|16945416 - gi\|16945416\|emb\|CAB91336.2\| probable multifunctional folic acid synthesis protein [Neurospora crassa...	0.0	[323..861]	[1..470]
FOKP_CHLMU, FOLK... - Folate synthesis bifunctional protein OS=Chlamydia muridarum GN=folKP PE=3 SV=1, (P82602) Folate syn... FOLKP_CHLMU - Folate synthesis bifunctional protein OS=Chlamydia muridarum (strain MoPn / Nigg) GN=folKP PE=3 SV=1	0.0	[335..863]	[2..448]
gi\|15149005 - gi\|15149005\|gb\|AAK20396.2\| dihydropterin pyrophosphokinase-dihydropteroate synthase [Plasmodium berg...	0.0	[210..856]	[49..662]
gi\|12330000 - gi\|12330000\|emb\|CAC24559.1\| dihydropterin pyrophosphokinase-dihydropteroate synthase [Plasmodium cha...	0.0	[210..862]	[49..672]

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Predicted Domain #1

Region A:
Residues: [1-220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINCKVIENR RTRFFPLVNA KLVKVIASSL INKFQSLPLA MSKLFSTVNS ARHSVPLGGM  60
   61 RDYVHIKKLE MNTVLGPDSW NQLMPQKCLL SLDMGTDFSK SAATDDLKYS LNYAVISRDL 120
  121 TNFVSKKKNW GSVSNLAKSV SQFVMDKYSG VECLNLEVQA DTTHIRSDHI SCIIQQERGN 180
  181 PESQEFDVVR ISELKMLTLI GVFTFERLKK QYVTLDIKLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.154902
Match:	1dhn__
Description:	7,8-dihydroneopterin aldolase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [221-318]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WPKKAELPPP VQSIIDNVVK FVEESNFKTV EALVESVSAV IAHNEYFQKF PDSPLVVKVL  60
   61 KLNAITATEG VGVSCIREPR EIAMVNIPYL SSIHESSD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [319-514]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKFQLSSSQN TPIEGKNTWK RAFLAFGSNI GDRFKHIQMA LQLLSREKTV KLRNISSIFE  60
   61 SEPMYFKDQT PFMNGCVEVE TLLTPSELLK LCKKIEYEEL QRVKHFDNGP RTIDLDIVMF 120
  121 LNSAGEDIIV NEPDLNIPHP RMLERTFVLE PLCELISPVH LHPVTAEPIV DHLKQLYDKQ 180
  181 HDEDTLWKLV PLPYRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	202.751666
Match:	1dy3A_
Description:	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [515-680]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVEPRFLKFK TATKLDEFTG ETNRITVSPT YIMAIFNATP DSFSDGGEHF ADIESQLNDI  60
   61 IKLCKDALYL HESVIIDVGG CSTRPNSIQA SEEEEIRRSI PLIKAIREST ELPQDKVILS 120
  121 IDTYRSNVAK EAIKVGVDII NDISGGLFDS NMFAVIAENP EICYIL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [740-752]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKAIDNGVKR WQI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	361.594777
Match:	1aj0__
Description:	Dihydropteroate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [681-739]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHTRGDISTM NRLAHYENFA LGDSIQQEFV HNTDIQQLDD LKDKTVLIRN VGQEIGERY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [753-864]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIDPGLGFAK TWKQNLQIIR HIPILKNYSF TMNSNNSQVY VNLRNMPVLL GPSRKKFIGH  60
   61 ITKDVDAKQR DFATGAVVAS CIGFGSDMVR VHDVKNCSKS IKLADAIYKG LE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	361.594777
Match:	1aj0__
Description:	Dihydropteroate synthetase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits