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Protein Overview: HER2

General Information:
Name(s) found: HER2 / YMR293C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 464 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: aerobic respiration [IEPLink to PubMed article][IMPLink to PubMed article]
    Molecular Function: amidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLKRSLKES IERLSSFQSK YNIFTSINPS PYSITNKKGT KETLTGCVAS IKDNIVTKDF  60
   61 PTTCASHILE NFKSPFDATV VKLLKQAGVH ILGKTNLDEF GMGSGGVHSI RGPVINPLYP 120
  121 HEDKKIMGGS SSGAAASVAC DLVDFALGTD TGGSVRLPAC YGSVLGFKPS YGRLSRFGVI 180
  181 AYSQSLDTVG ILSKKINVLR KVFHTLDKYD MKDPTSLSVE LRELIEGNKK VRRPLKVGIV 240
  241 KEFSHESMPI GFHRLYLSLL EKLINLGLEI YPVSIPSVKN CLPIYYTLSP AEAASNLSRY 300
  301 DGIRYGYRDS ELDIKDGILF APTRSKFGTE VKNRIILGNY NLCSDAFKNN FIKAEKLRVN 360
  361 LIDEFDGIFR FPNVLTNSKG NPDGLDLLIV PTSSKLPGSI RDFEEEEAKS PANSYINDVF 420
  421 TVPMSLAGLP SLSMPLKEKT PIGLQVVGQY GDDSTVLDFV ESIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BUD7 HER2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HER2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..464] PSI-BLAST 210.274545 No description for 1gr8A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
    		•  7.42914157198604 bayes_pls_golite062009
  • ligase activity
    		•  3.16753436373904 bayes_pls_golite062009
  • binding
    		•  1.29965583137169 bayes_pls_golite062009
  • catalytic activity
    		•  0.906509857495572 bayes_pls_golite062009
  • protein binding
    		•  0.583347864945253 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.301483171038292 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle