Protein Overview: IMP2

General Information:
Name(s) found:	IMP2 / YMR035W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798961\|emb\|CAA89151.1\| Imp2p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323678\|ref\|NP_013749.1\| Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p; Imp2p [NCBI NR] gi\|51013439\|gb\|AAT93013.1\| YMR035W [Saccharomyces cerevisiae] [NCBI NR] gi\|1170551\|sp\|P46972.1\|IMP2_YEAST RecName: Full=Mitochondrial inner membrane protease subunit 2 [NCBI NR] pir\|\|S53952 proteinase 2 precursor, mitochondrial inner membrane - yeast (Saccharomyces cerevisiae) [NCBI NR] Mitochondrial inner membrane protease subunit 2 OS=Saccharomyces cerevisiae GN=IMP2 PE=1 SV=1 [Swiss-Prot] IMP2 Mitochondrial inner membrane protease subunit [mips] Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p [SGD] IMP2, Chr XIII from 341141-341674 [yeast_orfs2] Chr XIII from 341141-341674 [yeastorf3.fasta] (P46972) Mitochondrial inner membrane protease subunit 2 (EC 3.4.99.-) [4932.FASTACCERV.txt] IMP2 SGDID:S0004638, Chr XIII from 341141-341674, Verified ORF [yeastflysequest.fasta] Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p [Saccharomyces cerevisiae]gi\|5101 [nrdb_11152004_Chlamydomonas] IMP2 SGDID:S000004638, Chr XIII from 341141-341674, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (bot [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Mitochondrial inner membrane protease subunit 2 [nr-271106-contam.fasta] Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p; Imp2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Imp2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YMR035W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] IMP2 SGDID:S000004638, Chr XIII from 341141-341674, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Mitochondrial inner membrane protease subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IMP2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] IMP2 SGDID:S000004638, Chr XIII from 341142-341675, Genome Release 64-1-1, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p" [yeast-030211-contam.fasta] IMP2 SGDID:S000004638, Chr XIII from 341142-341675, Genome Release 64-2-1, Verified ORF, "Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p" [20141208_orf_trans.fasta] TR6982\|c0_g1_i1\|g.4837 ORF TR6982\|c0_g1_i1\|g.4837 TR6982\|c0_g1_i1\|m.4837 type:complete len:178 (+) TR6982\|c0_g1_i1:81-614(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR6000\|c0_g1_i1\|g.4275 ORF TR6000\|c0_g1_i1\|g.4275 TR6000\|c0_g1_i1\|m.4275 type:complete len:178 (+) TR6000\|c0_g1_i1:135-668(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YMR035W SGDID:S000004638, Chr XIII from 341142-341675, Genome Release 64-1-1, Verified ORF, "Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_4392\|g.3060 ORF asmbl_4392\|g.3060 asmbl_4392\|m.3060 type:complete len:178 (+) asmbl_4392:58-591(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_4404\|g.2638 ORF ID=asmbl_4404\|g.2638 ID=asmbl_4404\|m.2638 type:complete len:178 (+) ID=asmbl_4404:133-666(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_4397\|g.2577 ORF ID=asmbl_4397\|g.2577 ID=asmbl_4397\|m.2577 type:complete len:178 (+) ID=asmbl_4397:58-591(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	177 amino acids
Gene Ontology:
Cellular Component:	mitochondrial inner membrane peptidase complex [IDA]
Biological Process:	protein processing involved in protein targeting to mitochondrion [IDA]
Molecular Function:	peptidase activity [IDA] mitochondrial inner membrane peptidase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRAGSSKRF LRNTLIAISW VPVLLTINNN VVHIAQVKGT SMQPTLNPQT ETLATDWVLL  60
   61 WKFGVKNPSN LSRDDIILFK APTNPRKVYC KRVKGLPFDT IDTKFPYPKP QVNLPRGHIW 120
  121 VEGDNYFHSI DSNTFGPISS GLVIGKAITI VWPPSRWGTD LKLSTGRDCI SKRAILE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		IMP1 IMP2
View Details	Qiu et al. (2008)		IMP1 IMP2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RGT2	IMP2	2	Unpublished Fields Lab Data
View Screen	MDM30	IMP2	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..177]	PSI-BLAST	66.0	Type 1 signal peptidase
2	View Details	[111..177]	FFAS03	3.67	Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2