YRC Public Data Repository - Protein Structure Prediction

Protein:	IMP2
Organism:	Saccharomyces cerevisiae
Length:	177 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMP2.

Description	E-value	Query Range	Subject Range
gi\|190408272 - gi\|190408272\|gb\|EDV11537.1\| protease [Saccharomyces cerevisiae RM11-1a] gi\|207342414 - gi\|207342414\|gb\|EDZ70188.1\| YMR035Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151946196 - gi\|151946196\|gb\|EDN64427.1\| protease [Saccharomyces cerevisiae YJM789] IMP2_YEAST - Mitochondrial inner membrane protease subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2... IMP2 - Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of ...	1.0E-47	[1..177]	[1..177]
gi\|17230467, gi\|... - gi\|17230467\|ref\|NP_487015.1\| hypothetical protein alr2975 [Nostoc sp. PCC 7120], gi\|17132069\|dbj\|BAB... gi\|25327710 - pir\|\|AH2177 hypothetical protein alr2975 [imported] - Nostoc sp. (strain PCC 7120)	2.0E-44	[3..160]	[14..190]
LEP_PSEFL - Signal peptidase I OS=Pseudomonas fluorescens GN=lepB PE=3 SV=1	1.0E-40	[5..156]	[54..268]
LEP2_SYNY3 - Probable signal peptidase I-2 OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=lepB2 PE=3 SV=1 gi\|7470864 - pir\|\|S75269 signal peptidase I (EC 3.4.21.89) slr1377 - Synechocystis sp. (strain PCC 6803) LEP2_SYNY3 - Probable signal peptidase I-2 OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=lepB2 PE=...	2.0E-40	[2..160]	[13..188]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-40	[3..156]	[53..268]
LEP_PSEAE - Signal peptidase I OS=Pseudomonas aeruginosa GN=lepB PE=3 SV=1 LEP_PSEAE - Signal peptidase I OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) G... gi\|116048684, gi... - gi\|53727324\|ref\|ZP_00138365.2\| COG0681: Signal peptidase I [Pseudomonas aeruginosa UCBPP-PA14], gi\|1... gi\|218773517, gi... - gi\|218893289\|ref\|YP_002442158.1\| signal peptidase I [Pseudomonas aeruginosa LESB58], gi\|218773517\|em... gi\|107100229 - gi\|107100229\|ref\|ZP_01364147.1\| hypothetical protein PaerPA_01001252 [Pseudomonas aeruginosa PACS2]	4.0E-40	[1..160]	[50..274]
gi\|15888376, gi\|... - gi\|17934941\|ref\|NP_531731.1\| prokaryotic type I signal peptidase [Agrobacterium tumefaciens str. C58... gi\|25290024, gi\|... - pir\|\|AI2703 prokaryotic type I signal peptidase [imported] - Agrobacterium tumefaciens (strain C58, ...	5.0E-40	[1..157]	[1..231]
gi\|15964824 - gi\|15964824\|ref\|NP_385177.1\| signal peptidase I transmembrane protein [Sinorhizobium meliloti 1021] gi\|15074003 - gi\|15074003\|emb\|CAC45650.1\| Probable signal peptidase I transmembrane protein [Sinorhizobium melilot...	1.0E-39	[1..155]	[1..222]
IMP1L_MOUSE - Mitochondrial inner membrane protease subunit 1 OS=Mus musculus GN=Immp1l PE=1 SV=1	2.0E-39	[4..166]	[3..160]
LEP_PHOLA - Signal peptidase I OS=Phormidium laminosum GN=lepB PE=3 SV=1	9.0E-39	[10..160]	[28..197]

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Predicted Domain #1

Region A:
Residues: [1-177]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRAGSSKRF LRNTLIAISW VPVLLTINNN VVHIAQVKGT SMQPTLNPQT ETLATDWVLL  60
   61 WKFGVKNPSN LSRDDIILFK APTNPRKVYC KRVKGLPFDT IDTKFPYPKP QVNLPRGHIW 120
  121 VEGDNYFHSI DSNTFGPISS GLVIGKAITI VWPPSRWGTD LKLSTGRDCI SKRAILE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.0
Match:	1kn9A_
Description:	Type 1 signal peptidase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [111-177]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVNLPRGHIW VEGDNYFHSI DSNTFGPISS GLVIGKAITI VWPPSRWGTD LKLSTGRDCI  60
   61 SKRAILE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.67
Match:	1t7dA
Description:	Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits