Protein Overview: CTK3

General Information:
Name(s) found:	CTK3 / YML112W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798888\|emb\|CAA89106.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323524\|ref\|NP_013595.1\| Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; Ctk3p [Sacch [NCBI NR] gi\|45269419\|gb\|AAS56090.1\| YML112W [Saccharomyces cerevisiae] [NCBI NR] gi\|1706182\|sp\|P46963.2\|CTK3_YEAST RecName: Full=CTD kinase subunit gamma; Short=CTDK-I gamma subunit; AltName: Full=CTD kinase subunit 3; AltName: Full=CTD kinase 32 kDa subunit [NCBI NR] pir\|\|S53960 CTK3 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] CTD kinase subunit gamma OS=Saccharomyces cerevisiae GN=CTK3 PE=1 SV=2 [Swiss-Prot] CTK3 Carboxy-terminal domain (CTD) kinase, gamma subunit [mips] Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity [SGD] CTK3, Chr XIII from 45063-45953 [yeast_orfs2] Chr XIII from 45063-45953 [yeastorf3.fasta] (P46963) CTD kinase gamma subunit (CTD kinase 32 kDa subunit) (CTDK-I gamma subunit) [4932.FASTACCERV.txt] CTK3 SGDID:S0004580, Chr XIII from 45063-45953, Verified ORF [yeastflysequest.fasta] Ctk3p [Saccharomyces cerevisiae]gi\|798888\|emb\|CAA89106.1\| unknown [Saccharomyces cerevisiae]gi\|45269419\|gb\|AAS56090.1\| YML112W [Saccharomyces cerevisiae]gi\|1077942\|pir\|\|S53960 CTK3 protein - yeast (Saccharomyces cerevisiae)gi\|1706182\|sp\|P46963\|CTK3_YE [nrdb_11152004_Chlamydomonas] CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p [yeast-200209-contam.fasta] CTD kinase subunit gamma (CTD kinase 32 kDa subunit) (CTDK-I gamma subunit) [nr-271106-contam.fasta] Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; Ctk3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YML112W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity" [yeast-bovrabprots.fasta] CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing" [yeast-contam_custom.fasta] [chemostatdb.fasta] CTD kinase subunit gamma OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTK3 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Genome Release 64-1-1, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity" [yeast-030211-contam.fasta] CTK3 SGDID:S000004580, Chr XIII from 45063-45953, Genome Release 64-2-1, Verified ORF, "Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta] YML112W SGDID:S000004580, Chr XIII from 45063-45953, Genome Release 64-1-1, Verified ORF, "Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	296 amino acids
Gene Ontology:
Cellular Component:	carboxy-terminal domain protein kinase complex [IPI]
Biological Process:	protein amino acid phosphorylation [IPI] positive regulation of RNA elongation [IDA]
Molecular Function:	cyclin-dependent protein kinase activity [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLEARLQF IQVLKNLQKT LHKTRDSITS SSTTTPPSSQ QKLNNDPIQF YLRNYRHHYE  60
   61 DFHQCLFDTT MKMDPLDRLD VVIYYVRIIR NLYPHSHSNT NVTKVLNEVL LMDIDLVFEL 120
  121 CLPCQDWKSL TNQATCKELF LDLSKLIHYD ATSVTHTPSD TTLIDATTWY SVKTERTTKD 180
  181 YKESLQRTES LLKDRDLKKL AFFQQFNSDT TAINPDLQTQ PTNANILLHR MEADRELHKR 240
  241 SKETSWYIER PSNDILDESE FKSLWTHFET TDSGFDKDDY KNIKALNDIA KASYIY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CTK1 CTK2 CTK3
View Details	(MIPS) Mewes HW, et al. (2004)		CTK1 CTK2 CTK3
View Details	Krogan NJ, et al. (2006)		CTK1 CTK2 CTK3
View Details	Gavin AC, et al. (2006)		CTK1 CTK2 CTK3
View Details	Gavin AC, et al. (2002)		CTK1 CTK2 CTK3 SSE2
View Details	Ho Y, et al. (2002)		CTK3 RVB1 STB3 UBA1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GBP2	CTK3	1	Unpublished Fields Lab Data
View Screen	CDC53	CTK3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	CTK3	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..296]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2