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Protein Overview: GLO1

General Information:
Name(s) found: GLO1 / YML004C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 326 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: glutathione metabolic process [IGILink to PubMed article]
    methylglyoxal catabolic process to D-lactate [IDALink to PubMed article]
    Molecular Function: lactoylglutathione lyase activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTDSTRYPI QIEKASNDPT LLLNHTCLRV KDPARTVKFY TEHFGMKLLS RKDFEEAKFS  60
   61 LYFLSFPKDD IPKNKNGEPD VFSAHGVLEL THNWGTEKNP DYKINNGNEE PHRGFGHICF 120
  121 SVSDINKTCE ELESQGVKFK KRLSEGRQKD IAFALGPDGY WIELITYSRE GQEYPKGSVG 180
  181 NKFNHTMIRI KNPTRSLEFY QNVLGMKLLR TSEHESAKFT LYFLGYGVPK TDSVFSCESV 240
  241 LELTHNWGTE NDPNFHYHNG NSEPQGYGHI CISCDDAGAL CKEIEVKYGD KIQWSPKFNQ 300
  301 GRMKNIAFLK DPDGYSIEVV PHGLIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GLO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 360.9897 Glyoxalase I (lactoylglutathione lyase)
    2 View Details [112..176] PSI-BLAST 360.9897 Glyoxalase I (lactoylglutathione lyase)
    3 View Details [177..326] PSI-BLAST 16.69897 Methylmalonyl-CoA epimerase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lactoylglutathione lyase activity
    		•  3.91334658149719 bayes_pls_golite062009
  • binding
    		•  1.68530537296561 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  1.44168339433372 bayes_pls_golite062009
  • catalytic activity
    		•  1.21778090213032 bayes_pls_golite062009
  • protein binding
    		•  0.28912087714501 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
    		•  0.0991913830827656 bayes_pls_golite062009
    2
    Term Confidence Notes
  • lactoylglutathione lyase activity
    		•  3.91334658149719 bayes_pls_golite062009
  • binding
    		•  1.68530537296561 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  1.44168339433372 bayes_pls_golite062009
  • catalytic activity
    		•  1.21778090213032 bayes_pls_golite062009
  • protein binding
    		•  0.28912087714501 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
    		•  0.0991913830827656 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle