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Catalysis of the elimination of H2S or substituted H2S. Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: lactoylglutathione lyase activity
Acc: GO:0004462
Aspect: Molecular Function
Desc: Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
Synonyms:
  • ketone-aldehyde mutase activity
  • glyoxylase I
  • (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity
  • glyoxalase I activity
  • (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
  • aldoketomutase activity
  • methylglyoxalase activity
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004462 - lactoylglutathione lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle