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Protein Overview: DCR2

General Information:
Name(s) found: DCR2 / YLR361C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 578 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: traversing start control point of mitotic cell cycle [IMPLink to PubMed article]
    Molecular Function: hydrolase activity, acting on ester bonds [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRLPRLYQR YLLYLVVFVV IALFYFLQAP RVEEHIGFDL ALPISHVDNL WFQNKGLEGF  60
   61 SNDDKLVVNI GYDECFHIGR FYEGCFNRHE LKSTLTDGHQ YLQRKRIHKD LRGSFGRRWF 120
  121 GKSEYLYYDV LYPALVDYFG SNLEKLNVEA VTGISKYPKD KSLPFMDVSI TFEPISIELL 180
  181 QKRSYISDIN ILFGVDCIQP IANWTLQKEF PLVKYRYSEP AYLTYKFVGT RPVDTGAQRL 240
  241 QETDEGKFKI VQLADLHLGV GESECIDEYP KHEACKADPK TETFVQQVLD IEKPQLVVFT 300
  301 GDQIMGDRSI QDSETVLLKA VAPVIARKIP WAMVWGNHDD EGSLTRWQLS EIASVLPYSL 360
  361 FKFSPHDTHD NTFGVGNYIY QIFSNNDTEV PVGTLYFLDS HKYSTVGKIY PGYDWIKESQ 420
  421 WKYIEDYHDV NLKFKTGLSM AFFHIPLPEY LNIESKTHPG EKNPLIGMYK EGVTAPKYNS 480
  481 EGITTLDRLS VDVVSCGHDH CNDYCLRDDS TPNKIWLCYG GGGGEGGYAG YGGTERRIRI 540
  541 YEINVNENNI HTWKRLNGSP KEIFDFQSML DGNSPESV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] deduced N/A No confident structure predictions are available.
    2 View Details [123..265]
    [305..364]    		 PSI-BLAST 68.69897 Purple acid phosphatase, N-terminal domain; Plant purple acid phosphatase, catalytic domain
    3 View Details [266..304]
    [365..578]    		 PSI-BLAST 68.69897 Purple acid phosphatase, N-terminal domain; Plant purple acid phosphatase, catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  6.72383231279941 bayes_pls_golite062009
  • phosphatase activity
    		•  6.15764991558074 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.12904381473271 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.45751396052657 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  4.88922581899552 bayes_pls_golite062009
  • hydrolase activity
    		•  4.13503349541242 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • binding
    		•  0.544021492899059 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  0.418135266012763 bayes_pls_golite062009
  • protein binding
    		•  0.028331237693133 bayes_pls_golite062009
  • protein kinase activity
    		•  0.00406388428352089 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle