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Protein Overview: SPH1

General Information:
Name(s) found: SPH1 / YLR313C [SGD]
Description(s) found:
Found 12 descriptions.
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  • Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 530 amino acids

    Gene Ontology:
    Cellular Component: polarisome [TASLink to PubMed article]
    incipient cellular bud site [IDALink to PubMed article]
    cellular bud tip [IDALink to PubMed articleLink to PubMed article]
    cellular bud neck [IDALink to PubMed articleLink to PubMed article]
    mating projection [IDALink to PubMed articleLink to PubMed article]
    Biological Process: bipolar cellular bud site selection [TASLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    actin filament organization [IPILink to PubMed article]
    Rho protein signal transduction [IPILink to PubMed article]
    Molecular Function: cytoskeletal regulatory protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISSELTNDQ IIDLISDYKN FKRIIEASVP EDDRRRNQNR QNRNKDLTKL SNVQFWQLTT  60
   61 DVNDELMKRL TDSGADASLN DLDLKRGKAQ SKLSRLKDAK FHKLILDIFT EIERRNLHHL 120
  121 DMGTHNNGLD EGDLNFYLND TLFESFKIND DFMSVNGIIS IEVFRELKTQ FTLYFQNTLH 180
  181 RIDPVDTTTT RLPILLETII KIAKLIGDLL PVLSSVSLQS SLENEIVYLK SALSHAITST 240
  241 RYFLTYGDLI PRIVAQSSIS EVIFAFCNIA QIVKIKSTSR DDISRNEGEL SDIEAGMKPL 300
  301 KIIEKVKNEK NGKDISSLGD SGSTAVSFPS SGKPITKKSD MPVVVASPSI SIIEKSESSI 360
  361 RESGKVRNNT SGETNLASVS PLKNTKNSSR ITSEPSPREG LPLKVVSNSR SPSPQGNTLP 420
  421 LIGKFRQDYQ ASPPKKVITK PVAETAKPYA NIPPAADVLY SPTVTKMRKF REKVQKFAPN 480
  481 SGLGLRISTS EENLNNSDVN STTHNANINN LVEFVESKSM VVLPMAGRAF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] ORFEUS 7.83 Monomeric isocitrate dehydrogenase
    2 View Details [116..136]
    [388..401]
    [431..530]    		 ORFEUS 7.83 Monomeric isocitrate dehydrogenase
    3 View Details [137..387]
    [402..430]    		 ORFEUS 7.83 Monomeric isocitrate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle