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View Structure Prediction Details

Protein: SPH1
Organism: Saccharomyces cerevisiae
Length: 530 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPH1.

Description E-value Query
Range
Subject
Range
gi|2258412 - gi|2258412|gb|AAB63284.1| Sph1p [Saccharomyces cerevisiae]
0.0 [1..526] [1..526]
SPAC3G9.05 - GTPase activating protein
YF75_SCHPO - Uncharacterized protein C3G9.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3G9.05...
1.0E-31 [14..115] [5..108]

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Predicted Domain #1
Region A:
Residues: [1-115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISSELTNDQ IIDLISDYKN FKRIIEASVP EDDRRRNQNR QNRNKDLTKL SNVQFWQLTT  60
   61 DVNDELMKRL TDSGADASLN DLDLKRGKAQ SKLSRLKDAK FHKLILDIFT EIERR

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.83
Match: 1itwA
Description: Monomeric isocitrate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [116-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLHHLDMGTH NNGLDEGDLN F

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [388-401]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSRITSEPSP REGL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [431-530]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASPPKKVITK PVAETAKPYA NIPPAADVLY SPTVTKMRKF REKVQKFAPN SGLGLRISTS  60
   61 EENLNNSDVN STTHNANINN LVEFVESKSM VVLPMAGRAF 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.83
Match: 1itwA
Description: Monomeric isocitrate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [137-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLNDTLFESF KINDDFMSVN GIISIEVFRE LKTQFTLYFQ NTLHRIDPVD TTTTRLPILL  60
   61 ETIIKIAKLI GDLLPVLSSV SLQSSLENEI VYLKSALSHA ITSTRYFLTY GDLIPRIVAQ 120
  121 SSISEVIFAF CNIAQIVKIK STSRDDISRN EGELSDIEAG MKPLKIIEKV KNEKNGKDIS 180
  181 SLGDSGSTAV SFPSSGKPIT KKSDMPVVVA SPSISIIEKS ESSIRESGKV RNNTSGETNL 240
  241 ASVSPLKNTK N

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [402-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLKVVSNSRS PSPQGNTLPL IGKFRQDYQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.83
Match: 1itwA
Description: Monomeric isocitrate dehydrogenase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle