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Protein Overview: NMT1

General Information:
Name(s) found: NMT1 / YLR195C [SGD]
Description(s) found:
Found 43 descriptions.
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  • N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: replicative cell aging [IMPLink to PubMed article]
    N-terminal peptidyl-glycine N-myristoylation [TASLink to PubMed article]
    Molecular Function: glycylpeptide N-tetradecanoyltransferase activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEDKAKKL ENLLKLLQLN NDDTSKFTQE QKKAMKDHKF WRTQPVKDFD EKVVEEGPID  60
   61 KPKTPEDISD KPLPLLSSFE WCSIDVDNKK QLEDVFVLLN ENYVEDRDAG FRFNYTKEFF 120
  121 NWALKSPGWK KDWHIGVRVK ETQKLVAFIS AIPVTLGVRG KQVPSVEINF LCVHKQLRSK 180
  181 RLTPVLIKEI TRRVNKCDIW HALYTAGIVL PAPVSTCRYT HRPLNWKKLY EVDFTGLPDG 240
  241 HTEEDMIAEN ALPAKTKTAG LRKLKKEDID QVFELFKRYQ SRFELIQIFT KEEFEHNFIG 300
  301 EESLPLDKQV IFSYVVEQPD GKITDFFSFY SLPFTILNNT KYKDLGIGYL YYYATDADFQ 360
  361 FKDRFDPKAT KALKTRLCEL IYDACILAKN ANMDVFNALT SQDNTLFLDD LKFGPGDGFL 420
  421 NFYLFNYRAK PITGGLNPDN SNDIKRRSNV GVVML

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NMT1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] PSI-BLAST 11000.0 N-myristoyl transferase, NMT
    2 View Details [215..455] PSI-BLAST 11000.0 N-myristoyl transferase, NMT


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle