Protein Overview: YPS3

General Information:
Name(s) found:	YPS3 / YLR121C [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [SGD]
Organism:	Saccharomyces cerevisiae
Length:	508 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA][ISS] anchored to plasma membrane [IDA][IPI]
Biological Process:	fungal-type cell wall organization [IEP][IPI] protein metabolic process [IDA][ISS]
Molecular Function:	aspartic-type endopeptidase activity [IDA][ISS] structural constituent of cell wall [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLQLAAVAT LAVLTSPAFG RVLPDGKYVK IPFTKKKNGD NGELSKRSNG HEKFVLANEQ  60
   61 SFYSVELAIG TPSQNLTVLL DTGSADLWVP GKGNPYCGSV MDCDQYGVFD KTKSSTFKAN 120
  121 KSSPFYAAYG DGTYAEGAFG QDKLKYNELD LSGLSFAVAN ESNSTFGVLG IGLSTLEVTY 180
  181 SGKVAIMDKR SYEYDNFPLF LKHSGAIDAT AYSLFLNDES QSSGSILFGA VDHSKYEGQL 240
  241 YTIPLVNLYK SQGYQHPVAF DVTLQGLGLQ TDKRNITLTT TKLPALLDSG TTLTYLPSQA 300
  301 VALLAKSLNA SYSKTLGYYE YTCPSSDNKT SVAFDFGGFR INAPLSDFTM QTSVGTCVLA 360
  361 IIPQAGNATA ILGDSFLRNA YVVYDLDNYE ISLAQAKYGT GKENVEVIKS TVPSAIRAPS 420
  421 YNNTWSNYAS ATSGGNIFTT VRTFNGTSTA TTTRSTTTKK TNSTTTAKST HKSKRALQRA 480
  481 ATNSASSIRS TLGLLLVPSL LILSVFFS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		DCW1 DFG5 YLR194C YPS3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PEX4	YPS3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YPS3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..64] [208..244] [379..433]	PSI-BLAST	918.68867	No description for 1ypsA_ was found.
2	View Details	[65..207] [245..378]	PSI-BLAST	918.68867	No description for 1ypsA_ was found.
3	View Details	[434..508]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
aspartic-type endopeptidase activity	7.9145950161796	bayes_pls_golite062009
aspartic-type peptidase activity	7.9145950161796	bayes_pls_golite062009
peptidase activity	5.78181196721293	bayes_pls_golite062009
endopeptidase activity	5.4888481808613	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	5.39972232367526	bayes_pls_golite062009
hydrolase activity	4.34796304893506	bayes_pls_golite062009
catalytic activity	1.54514410489082	bayes_pls_golite062009
binding	1.10054369202721	bayes_pls_golite062009
receptor binding	0.561225023505917	bayes_pls_golite062009
protein binding	0.193907750061394	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2