Protein Overview: EMP46

General Information:
Name(s) found:	EMP46 / YLR080W [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport [SGD]
Organism:	Saccharomyces cerevisiae
Length:	444 amino acids
Gene Ontology:
Cellular Component:	Golgi membrane [IDA] ER to Golgi transport vesicle [IPI]
Biological Process:	ER to Golgi vesicle-mediated transport [IGI][ISS]
Molecular Function:	glycoprotein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTRKTASSL QLLGKITGTK AGTKQKKMNF INGLIWLYMC VWMVHGKVTQ KDELKWNKGY  60
   61 SLPNLLEVTD QQKELSQWTL GDKVKLEEGR FVLTPGKNTK GSLWLKPEYS IKDAMTIEWT 120
  121 FRSFGFRGST KGGLAFWLKQ GNEGDSTELF GGSSKKFNGL MILLRLDDKL GESVTAYLND 180
  181 GTKDLDIESS PYFASCLFQY QDSMVPSTLR LTYNPLDNHL LKLQMDNRVC FQTRKVKFMG 240
  241 SSPFRIGTSA INDASKESFE ILKMKLYDGV IEDSLIPNVN PMGQPRVVTK VINSQTGEES 300
  301 FREKMPFSDK EESITSNELF EKMNKLEGKI MANDIDPLLR KMNKIVENER ELIQRLRPLL 360
  361 DLKKTAISDD SFQDFLSMNA NLDRLIKEQE KIRQDAKLYG KQTKGHDEIF SKISVWLALL 420
  421 IFIMITLAYY MFRINQDIKK VKLL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		EMP46 GYL1 YOS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD6	EMP46	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	EMP46	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..277]	PSI-BLAST	81.522879	Carbohydrate-recognition domain of P58/ERGIC-53
2	View Details	[278..444]	PSI-BLAST	2.69897	Heavy meromyosin subfragment

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2