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Protein Overview: DCW1

General Information:
Name(s) found: DCW1 / YKL046C [SGD]
Description(s) found:
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  • gi|6322805|ref|NP_012878.1| Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; Dcw1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|549674|sp|P36091.1|DCW1_YEAST RecName: Full=Mannan endo-1,6-alpha-mannosidase DCW1; AltName: Full=Endo-alpha-1->6-D-mannanase DCW1; AltName: Full=Defective cell wall 1; Flags: Precursor [NCBI NR]
  • pir||S37867 hypothetical protein YKL046c precursor - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486062|emb|CAA81881.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Mannan endo-1,6-alpha-mannosidase DCW1 OS=Saccharomyces cerevisiae GN=DCW1 PE=1 SV=1 [Swiss-Prot]
  • DCW1 Glycosylphosphatidylinositol (GPI)-anchored membrane protein, required for cell wall biogenesis [mips]
  • Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p [SGD]
  • YKL046C, Chr XI from 350916-352265, reverse complement [yeast_orfs2]
  • Chr XI from 350916-352265, reverse complement [yeastorf3.fasta]
  • Chr XI from 352265-350916, reverse complement [yeastorf5.fasta]
  • (P36091) Hypothetical 49.6 kDa protein in ELM1-PRI2 intergenic region [4932.FASTACCERV.txt]
  • DCW1 SGDID:S0001529, Chr XI from 352269-350920, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Dcw1p [Saccharomyces cerevisiae]gi|486062|emb|CAA81881.1| unnamed protein product [Saccharomyces cerevisiae]gi|539160|pir||S37867 hypothetical protein YKL046c precursor - yeast (Saccharomyces cerevisiae)gi|549674|sp|P36091|DCW1_YEAST Mannan endo-1,6-a [nrdb_11152004_Chlamydomonas]
  • (P36091) Mannan endo-1,6-alpha-mannosidase DCW1 precursor (EC 3.2.1.101) (Endo-alpha-1->6-D-mannanase DCW1) (Defective cell wall 1) [cerv4932.FASTAC]
  • DCW1 SGDID:S000001529, Chr XI from 352268-350919, reverse complement, Verified ORF, "Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; Dcw1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mannan endo-1,6-alpha-mannosidase DCW1 precursor (Endo-alpha-1->6-D-mannanase DCW1) (Defective cell wall 1) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Mannan endo-1,6-alpha-mannosidase DCW1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCW1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DCW1 SGDID:S000001529, Chr XI from 352624-351275, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" [yeast-030211-contam.fasta]
  • DCW1 SGDID:S000001529, Chr XI from 352624-351275, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" [20141208_orf_trans.fasta]
  • TR3959|c0_g1_i1|g.2812 ORF TR3959|c0_g1_i1|g.2812 TR3959|c0_g1_i1|m.2812 type:complete len:450 (+) TR3959|c0_g1_i1:238-1587(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YKL046C SGDID:S000001529, Chr XI from 352624-351275, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_6446|g.4678 ORF asmbl_6446|g.4678 asmbl_6446|m.4678 type:complete len:450 (+) asmbl_6446:234-1583(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_6467|g.4059 ORF ID=asmbl_6467|g.4059 ID=asmbl_6467|m.4059 type:complete len:450 (+) ID=asmbl_6467:234-1583(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 449 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    anchored to plasma membrane [IDALink to PubMed article]
    Biological Process: fungal-type cell wall biogenesis [IDALink to PubMed article]
    budding cell bud growth [IGILink to PubMed article]
    Molecular Function: mannosidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVNKVIGLL GVLFATRFTN AVELDLDNYE SLQNATSLIA YGLMDYYTGN QYGKTVGMFS  60
   61 DPYYWWEAGG AWGCMLDYWF FMDNDTYNDE IIAAMIHQAG DDNDYIPLNQ STTEGNDDQA 120
  121 FWGIAAMTAA ERNFTNPPEN EPQWLYLAQA VFNTMALRWD ADSCGGGLRW QIFVWNSGYD 180
  181 YKNTVSNGAL FHIAARLARY TGNQTYVDWA EKVYEWMVGV NLISNGTYKY VYDGVSIDDN 240
  241 CTKVTSYQWT YNQGLLLAGS AYLYNFTGSD LWHTRTKEFL NASQVFFHDG IVYEAACQGP 300
  301 NSCNTDQRSF KAYFARFLGV TAQLVPETRN QIMSWLNTSA IAAAKSCSGG TDGHTCGLNW 360
  361 FNGTWDGMYG LGEQMSALEV MVNTRALDKP APYTAENGGS SVGDGAAGTQ AQPTNLAPLN 420
  421 ITKGSKAGAG IITAVIGISI VACALWLVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP16 DCW1 FIT1 RPL29 RPP1A RPS26A SEM1 YMR118C
    View Details Qiu et al. (2008) DCW1 DFG5 YLR194C YPS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DCW1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..258] ORFEUS 8.89 Class I alpha-1;2-mannosidase, catalytic domain
    2 View Details [259..449] ORFEUS 8.89 Class I alpha-1;2-mannosidase, catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • trehalase activity
    		•  4.23942428290504 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.78681366425382 bayes_pls_golite062009
  • alpha,alpha-trehalase activity
    		•  3.55712700159445 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  3.06084463737498 bayes_pls_golite062009
  • hydrolase activity
    		•  2.4324152075641 bayes_pls_golite062009
  • glucosidase activity
    		•  1.29725707798041 bayes_pls_golite062009
  • binding
    		•  1.09492132758288 bayes_pls_golite062009
  • catalytic activity
    		•  1.0882760267763 bayes_pls_golite062009
  • glucan 1,4-alpha-glucosidase activity
    		•  0.459801253504163 bayes_pls_golite062009
  • protein binding
    		•  0.208998323911823 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  0.0402220178011703 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle