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Protein Overview: YJL216C

General Information:
Name(s) found: YJL216C [SGD]
Description(s) found:
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  • gi|729990|sp|P40884.1|MALX1_YEAST RecName: Full=Probable alpha-glucosidase YJL216C; AltName: Full=Maltase [NCBI NR]
  • gi|6322245|ref|NP_012319.1| Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; Yjl216cp [ [NCBI NR]
  • gi|496946|emb|CAA83995.1| ORF [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50769 alpha-glucosidase homolog YJL216c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1015604|emb|CAA89513.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P40884) Probable alpha-glucosidase YJL216C (EC 3.2.1.20) (Maltase) [Swiss-Prot]
  • Probable alpha-glucosidase YJL216C OS=Saccharomyces cerevisiae GN=YJL216C PE=2 SV=1 [Swiss-Prot]
  • Strong similarity to alpha-D-glucosidase, Fsp2p and Mal62p [mips]
  • Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon [SGD]
  • YJL216C, Chr X from 24341-26086, reverse complement [yeast_orfs2]
  • Chr X from 24341-26086, reverse complement [yeastorf3.fasta]
  • Chr X from 26086-24341, reverse complement [yeastorf5.fasta]
  • YJL216C SGDID:S0003752, Chr X from 26086-24341, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance [Saccharomyces cerevisiae]gi|1015604|emb|CAA89513.1| unnamed protein product [Saccharomyces cerevisiae]gi|496946|emb|CAA83995.1| ORF [Sac [nrdb_11152004_Chlamydomonas]
  • YJL216C SGDID:S000003752, Chr X from 26086-24341, reverse complement, Uncharacterized ORF, "Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YJL216C SGDID:S000003752, Chr X from 26086-24341, reverse complement, Uncharacterized ORF, "Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved [yeast-contam.fasta]
  • ORF [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable alpha-glucosidase YJL216C (Maltase) [nr-271106-contam.fasta]
  • Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; Yjl216cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YJL216C SGDID:S000003752, Chr X from 26086-24341, reverse complement, Uncharacterized ORF, "Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • IMA5 SGDID:S000003752, Chr X from 26086-24341, Genome Release 64-1-1, reverse complement, Verified ORF, "Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose" [yeast-030211-contam.fasta]
  • IMA5 SGDID:S000003752, Chr X from 26086-24341, Genome Release 64-2-1, reverse complement, Verified ORF, "Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro" [20141208_orf_trans.fasta]
  • YJL216C SGDID:S000003752, Chr X from 26086-24341, Genome Release 64-1-1, reverse complement, Verified ORF, "Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: alpha-galactosidase activity [ISSLink to PubMed articleLink to PubMed article]
    hydrolase activity, hydrolyzing O-glycosyl compounds [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIIHNPKWW KEATVYQIYP ASFKDSNNDG WGDLAGITSK LDYVKELGVD AIWVCPFYDS  60
   61 PQEDMGYDIA NYEKVWPRYG TNEDCFQMIE EAHKRGIKVI VDLVINHCSE EHEWFKESRS 120
  121 SKANPKRDWF FWRPPKGYDE KGNPIPPNNW RSFFGGSAWR YDEKTGEFFL HVFALGQPDF 180
  181 NWENEECRKA IYDSSVGYWL RHNVDGFRID VGSMYSKVEG LPDAPITDPT VPYQKGTEFF 240
  241 INGPRIHEYH KEMHNYMLSQ VPEGKEIMTV GEVGIGNEDD FRVYTSAKEG ELNMMFNFKH 300
  301 TSVGENPKCK YELIPFTLKD FKLALAESFL FIENTDCWST IYLENHDQPR SVSRFGSDSP 360
  361 KWREISSKML ATLIISLTGT VFIYQGQELG MPNFKNRKIE QIKCVEGTGT YAAIKRDYGE 420
  421 DSEKMKKFFE ALALISRDHG RTPFPWSADE PSAGFSKDAK PWIDMNESFR DGINAEAELK 480
  481 DKNSVFFFWK KALQVRKEHK DILVYGHNFQ FIDLDNDKLF MFTKDTDNKK MFAVFNFSSD 540
  541 NTDFSVPDNE ASYTMFFGNY ANSNGDSRTL QPWEGRLYLL K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 1358.0 Oligo-1,6-glucosidase; Oligo-1,6, glucosidase
    2 View Details [298..581] PSI-BLAST 1358.0 Oligo-1,6-glucosidase; Oligo-1,6, glucosidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  4.11319792356479 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.92012282533754 bayes_pls_golite062009
  • hydrolase activity
    		•  3.21770945631891 bayes_pls_golite062009
  • chitinase activity
    		•  2.45357334610104 bayes_pls_golite062009
  • structural molecule activity
    		•  2.28030619331997 bayes_pls_golite062009
  • trehalase activity
    		•  2.11042620996316 bayes_pls_golite062009
  • alpha-amylase activity
    		•  2.09193270404736 bayes_pls_golite062009
  • amylase activity
    		•  2.03484942782894 bayes_pls_golite062009
  • catalytic activity
    		•  1.85569074294201 bayes_pls_golite062009
  • alpha-glucosidase activity
    		•  0.96543619590958 bayes_pls_golite062009
  • glucosidase activity
    		•  0.766503513427695 bayes_pls_golite062009
  • hexosaminidase activity
    		•  0.763360027922833 bayes_pls_golite062009
  • binding
    		•  0.63693798355947 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.4998423581103 bayes_pls_golite062009
  • maltase activity
    		•  0.442635030512661 bayes_pls_golite062009
  • sugar binding
    		•  0.36459095255871 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.266938437560648 bayes_pls_golite062009
  • beta-N-acetylhexosaminidase activity
    		•  0.263065978664289 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle