Protein Overview: LSB6

General Information:
Name(s) found:	LSB6 / YJL100W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|728710\|emb\|CAA59394.1\| orf 12 [Saccharomyces cerevisiae] [NCBI NR] gi\|6322361\|ref\|NP_012435.1\| Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Lsb6p [Saccharomyces cerevisiae] [NCBI NR] gi\|1176483\|sp\|P42951.1\|LSB6_YEAST RecName: Full=Phosphatidylinositol 4-kinase LSB6; Short=PtdIns-4-kinase; Short=PI4-kinase; AltName: Full=LAS seventeen-binding protein 6; Short=LAS17-binding protein 6 [NCBI NR] pir\|\|S53387 hypothetical protein YJL100w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1008280\|emb\|CAA89395.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Phosphatidylinositol 4-kinase LSB6 OS=Saccharomyces cerevisiae GN=LSB6 PE=1 SV=1 [Swiss-Prot] LSB6 LAs17 Binding protein [mips] Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [SGD] YJL100W, Chr X from 236960-238783 [yeast_orfs2] Chr X from 236960-238783 [yeastorf3.fasta] (P42951) Hypothetical 70.2 kDa protein in GSH1-CHS6 intergenic region [4932.FASTACCERV.txt] LSB6 SGDID:S0003636, Chr X from 237180-239003, Verified ORF [yeastflysequest.fasta] Lsb6p [Saccharomyces cerevisiae]gi\|1008280\|emb\|CAA89395.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|728710\|emb\|CAA59394.1\| orf 12 [Saccharomyces cerevisiae]gi\|1176483\|sp\|P42951\|LSB6_YEAST Phosphatidylinositol 4-kinase LSB6 (PI4-kinase) (Ptd [nrdb_11152004_Chlamydomonas] (P42951) Phosphatidylinositol 4-kinase LSB6 (EC 2.7.1.67) (PI4-kinase) (PtdIns-4-kinase) [cerv4932.FASTAC] LSB6 SGDID:S000003636, Chr X from 237180-239003, Verified ORF, "Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] LSB6 SGDID:S000003636, Chr X from 237259-239082, Verified ORF, "Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [yeast-contam.fasta] LSB6 SGDID:S000003636, Chr X from 237259-239082, Verified ORF, "Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] LSB6 SGDID:S000003636, Chr X from 237258-239081, Verified ORF, "Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [yeast-200209-contam.fasta] Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Lsb6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] orf 12 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Phosphatidylinositol 4-kinase LSB6 (PI4-kinase) (PtdIns-4-kinase) [nr-271106-contam.fasta] [chemostatdb.fasta] Phosphatidylinositol 4-kinase LSB6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LSB6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] LSB6 SGDID:S000003636, Chr X from 237263-239086, Genome Release 64-1-1, Verified ORF, "Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [yeast-030211-contam.fasta] LSB6 SGDID:S000003636, Chr X from 237263-239086, Genome Release 64-2-1, Verified ORF, "Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [20141208_orf_trans.fasta] YJL100W SGDID:S000003636, Chr X from 237263-239086, Genome Release 64-1-1, Verified ORF, "Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	607 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] cytoplasm [IDA] vacuolar membrane [IDA] plasma membrane [IDA]
Biological Process:	actin filament organization [IPI] phosphoinositide phosphorylation [IDA] inositol lipid-mediated signaling [TAS]
Molecular Function:	1-phosphatidylinositol 4-kinase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNEAYQHDH TVNPHQKIVV NSYDWLQFRD EQDHCKSKNP ITHASPGVGS NAQNSDIAEA  60
   61 PQVFHPSYQS LVNVPSESPR PDQTSGSNPA VGLLHNAEDK ASGQEEEGSQ YEIQYSVFRP 120
  121 LHAYPTKGLA YEQLRRKEEQ EQRENFNHLV SDCIEAVETF GRELERIQTG SSGSYFVYGT 180
  181 RADESVPVGV FKPKDEEPYG PFSPKWTKWA HRTFFPCLFG RSCLIPNLGY ICESAASLLD 240
  241 RRLETHLVPY TDTASIESFN FYDNRKKWVL GYNLQKKKQK KLGSFQLFLK EYINADEFFH 300
  301 KYPLPGMYSD VKHSFHRKSS GEDINHKPET TRNLTDETEP SKQINSSPIS TESEENSKFE 360
  361 WTESSLSQFR LELEKLIILD YIMRNTDRGL DNWMVKLIKL SNNKWRLKLA AIDNGLSFPW 420
  421 KHPDEWRLYP YGWLYLPLQL LAKPFSEQMR SHFLPILTST NWWEESYQEF LALFSRDQDF 480
  481 NVRMWKKQWA VLKGQAFNVV ETLKDPRQGP LELVRRTRCQ VIDEKMQVPC CPPPVSIFKN 540
  541 AIDEPIGSYS TSPMVLPSTP STIPFHAHNQ SNSNPVYYDS TLHPFANKTV IAERLQIVNS 600
  601 TPVFTWC

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		LSB6 TOR2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RLF2	phosphorylation data - cascade search	Green EM, et al (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSB6	KIN3	2	Unpublished Fields Lab Data
View Screen	SNX41	LSB6	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..107]	deduced	N/A	No confident structure predictions are available.
2	View Details	[108..401]	MSA	9.02597	View MSA. No confident structure predictions are available.
3	View Details	[402..555]	MSA	1.01596	View MSA. No confident structure predictions are available.
4	View Details	[556..607]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2