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Protein Overview: SER33

General Information:
Name(s) found: SER33 / YIL074C [SGD]
Description(s) found:
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  • gi|731830|sp|P40510.1|SER33_YEAST RecName: Full=D-3-phosphoglycerate dehydrogenase 2; Short=3-PGDH 2 [NCBI NR]
  • gi|6322116|ref|NP_012191.1| 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p; Ser33p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48370 probable phosphoglycerate dehydrogenase (EC 1.1.1.95) YIL074c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|556873|emb|CAA86096.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • D-3-phosphoglycerate dehydrogenase 2 OS=Saccharomyces cerevisiae GN=SER33 PE=1 SV=1 [Swiss-Prot]
  • (P40510) D-3-phosphoglycerate dehydrogenase 2 (EC 1.1.1.95) (3-PGDH 2) [Swiss-Prot]
  • SER33 3-phosphoglycerate dehydrogenase [mips]
  • 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p [SGD]
  • SER33, Chr IX from 221078-222487, reverse complement [yeast_orfs2]
  • Chr IX from 221078-222487, reverse complement [yeastorf3.fasta]
  • Chr IX from 222487-221078, reverse complement [yeastorf5.fasta]
  • SER33 SGDID:S0001336, Chr IX from 222487-221078, reverse complement, Verified ORF [yeastflysequest.fasta]
  • 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p [Saccharomyces cerevisiae]gi|556873|emb|CAA86096.1| unnamed protein product [Saccharomyces cerevisiae]gi|731830|sp|P40510|SE33_YEAST D-3-phos [nrdb_11152004_Chlamydomonas]
  • SER33 SGDID:S000001336, Chr IX from 222487-221078, reverse complement, Verified ORF, "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p; Ser33p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • D-3-phosphoglycerate dehydrogenase 2 (3-PGDH 2) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • D-3-phosphoglycerate dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SER33 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SER33 SGDID:S000001336, Chr IX from 222490-221081, Genome Release 64-1-1, reverse complement, Verified ORF, "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p" [yeast-030211-contam.fasta]
  • SER33 SGDID:S000001336, Chr IX from 222490-221081, Genome Release 64-2-1, reverse complement, Verified ORF, "3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YIL074C SGDID:S000001336, Chr IX from 222490-221081, Genome Release 64-1-1, reverse complement, Verified ORF, "3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: serine family amino acid biosynthetic process [IMPLink to PubMed article]
    Molecular Function: phosphoglycerate dehydrogenase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYSAADNLQ DSFQRAMNFS GSPGAVSTSP TQSFMNTLPR RVSITKQPKA LKPFSTGDMN  60
   61 ILLLENVNAT AIKIFKDQGY QVEFHKSSLP EDELIEKIKD VHAIGIRSKT RLTEKILQHA 120
  121 RNLVCIGCFC IGTNQVDLKY AASKGIAVFN SPFSNSRSVA ELVIGEIISL ARQLGDRSIE 180
  181 LHTGTWNKVA ARCWEVRGKT LGIIGYGHIG SQLSVLAEAM GLHVLYYDIV TIMALGTARQ 240
  241 VSTLDELLNK SDFVTLHVPA TPETEKMLSA PQFAAMKDGA YVINASRGTV VDIPSLIQAV 300
  301 KANKIAGAAL DVYPHEPAKN GEGSFNDELN SWTSELVSLP NIILTPHIGG STEEAQSSIG 360
  361 IEVATALSKY INEGNSVGSV NFPEVSLKSL DYDQENTVRV LYIHRNVPGV LKTVNDILSD 420
  421 HNIEKQFSDS HGEIAYLMAD ISSVNQSEIK DIYEKLNQTS AKVSIRLLY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SER3 SER33
    View Details Krogan NJ, et al. (2006) SER3 SER33
    View Details Gavin AC, et al. (2002) PHO12 SER3 SER33
    View Details Qiu et al. (2008) SER3 SER33

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SER33 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152]
    [355..376]    		 PSI-BLAST 1164.0 Phosphoglycerate dehydrogenase; Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain
    2 View Details [153..354]
    [377..469]    		 PSI-BLAST 1164.0 Phosphoglycerate dehydrogenase; Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity, transferring aldehyde or ketonic groups
    		•  4.08159331332211 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  3.48670706716817 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.69771604880532 bayes_pls_golite062009
  • phosphoglycerate dehydrogenase activity
    		•  0.639509916626856 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • binding
    		•  0.355184540089764 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.310712203379158 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle