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Protein Overview: ERG9

General Information:
Name(s) found: ERG9 / YHR190W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TAS]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: farnesyl-diphosphate farnesyltransferase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKLLQLALH PVEMKAALKL KFCRTPLFSI YDQSTSPYLL HCFELLNLTS RSFAAVIREL  60
   61 HPELRNCVTL FYLILRALDT IEDDMSIEHD LKIDLLRHFH EKLLLTKWSF DGNAPDVKDR 120
  121 AVLTDFESIL IEFHKLKPEY QEVIKEITEK MGNGMADYIL DENYNLNGLQ TVHDYDVYCH 180
  181 YVAGLVGDGL TRLIVIAKFA NESLYSNEQL YESMGLFLQK TNIIRDYNED LVDGRSFWPK 240
  241 EIWSQYAPQL KDFMKPENEQ LGLDCINHLV LNALSHVIDV LTYLAGIHEQ STFQFCAIPQ 300
  301 VMAIATLALV FNNREVLHGN VKIRKGTTCY LILKSRTLRG CVEIFDYYLR DIKSKLAVQD 360
  361 PNFLKLNIQI SKIEQFMEEM YQDKLPPNVK PNETPIFLKV KERSRYDDEL VPTQQEEEYK 420
  421 FNMVLSIILS VLLGFYYIYT LHRA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) EHT1 ERG9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ERG9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164]
    [180..199]    		 PSI-BLAST 917.9897 Squalene synthase
    2 View Details [165..179]
    [200..444]    		 PSI-BLAST 917.9897 Squalene synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • prenyltransferase activity
    		•  5.34003736022396 bayes_pls_golite062009
  • farnesyl-diphosphate farnesyltransferase activity
    		•  5.04441642023356 bayes_pls_golite062009
  • geranyltranstransferase activity
    		•  3.86169009960142 bayes_pls_golite062009
  • farnesyltranstransferase activity
    		•  3.11591733497708 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • dimethylallyltranstransferase activity
    		•  1.91559289231283 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  1.82540911622956 bayes_pls_golite062009
  • transferase activity
    		•  1.77738506203957 bayes_pls_golite062009
  • binding
    		•  0.0206192709356209 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle