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Protein Overview: PHB2

General Information:
Name(s) found: PHB2 / YGR231C [SGD]
Description(s) found:
Found 16 descriptions.
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  • Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 315 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of proteolysis [IMPLink to PubMed article][IPILink to PubMed article]
    protein folding [IDALink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    replicative cell aging [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRSPGEFQR YAKAFQKQLS KVQQTGGRGQ VPSPRGAFAG LGGLLLLGGG ALFINNALFN  60
   61 VDGGHRAIVY SRIHGVSSRI FNEGTHFIFP WLDTPIIYDV RAKPRNVASL TGTKDLQMVN 120
  121 ITCRVLSRPD VVQLPTIYRT LGQDYDERVL PSIVNEVLKA VVAQFNASQL ITQREKVSRL 180
  181 IRENLVRRAS KFNILLDDVS ITYMTFSPEF TNAVEAKQIA QQDAQRAAFV VDKARQEKQG 240
  241 MVVRAQGEAK SAELIGEAIK KSRDYVELKR LDTARDIAKI LASSPNRVIL DNEALLLNTV 300
  301 VDARIDGRGQ INSEG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..208]
    [237..268]    		 PSI-BLAST 770.156545 No description for 1lu7A_ was found.
    2 View Details [209..236]
    [269..315]    		 PSI-BLAST 770.156545 No description for 1lu7A_ was found.
    3 View Details [207..315] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.10215477176861 bayes_pls_golite062009
  • protein binding
    		•  0.769979871341236 bayes_pls_golite062009
  • structural molecule activity
    		•  0.591437172549816 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle