YRC Public Data Repository - Protein Structure Prediction

Protein:	PHB2
Organism:	Saccharomyces cerevisiae
Length:	315 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHB2.

Description	E-value	Query Range	Subject Range
PHB_RAT - Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1 tr\|G3HJP6\|G3HJP6... - Prohibitin OS=Cricetulus griseus GN=I79_010895 PE=4 SV=1 PHB_MOUSE - Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1	5.0E-69	[39..301]	[9..271]
gi\|61362617, gi\|... - gi\|61362624\|gb\|AAX42254.1\| prohibitin [synthetic construct], gi\|61362617\|gb\|AAX42253.1\| prohibitin [... HGNC:8912\|MIM:17... - null PHB - prohibitin PHB_BOVIN - Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1 gi\|158906128, gi... - gi\|160333845\|ref\|NP_001103918.1\| prohibitin [Felis catus], gi\|158906128\|gb\|ABW82705.1\| prohibitin [F... gi\|158442066, gi... - gi\|158819069\|ref\|NP_001103649.1\| prohibitin [Canis lupus familiaris], gi\|158442066\|gb\|ABW38778.1\| pr... gi\|109114258, gi... - gi\|109114260\|ref\|XP_001093569.1\| PREDICTED: similar to prohibitin isoform 7 [Macaca mulatta], gi\|109... ENSCJAT00000014086 - null gi\|114666273, gi... - gi\|55646807\|ref\|XP_511949.1\| PREDICTED: prohibitin isoform 7 [Pan troglodytes], gi\|114666277\|ref\|XP_...	8.0E-69	[39..301]	[9..271]
PHB4_ARATH - Prohibitin-4, mitochondrial OS=Arabidopsis thaliana GN=PHB4 PE=1 SV=1	6.0E-67	[28..300]	[2..275]
gi\|220944624, gi... - gi\|220954406\|gb\|ACL89746.1\| l(2)37Cc-PA [synthetic construct], gi\|220944624\|gb\|ACL84855.1\| l(2)37Cc-... gi\|190657476, gi... - gi\|194879728\|ref\|XP_001974289.1\| GG21649 [Drosophila erecta], gi\|190657476\|gb\|EDV54689.1\| GG21649 [D... l(2)37Cc-PA, l(2... - The gene lethal (2) 37Cc is referred to in FlyBase by the symbol Dmel\l(2)37Cc (CG10691, FBgn0002031... gi\|194134208, gi... - gi\|195345029\|ref\|XP_002039078.1\| GM17028 [Drosophila sechellia], gi\|194134208\|gb\|EDW55724.1\| GM17028... gi\|195484379, gi... - gi\|195484379\|ref\|XP_002090669.1\| GE12669 [Drosophila yakuba], gi\|194176770\|gb\|EDW90381.1\| GE12669 [D... gi\|194191900, gi... - gi\|195580095\|ref\|XP_002079891.1\| GD21777 [Drosophila simulans], gi\|194191900\|gb\|EDX05476.1\| GD21777 ...	7.0E-67	[45..306]	[14..276]
gi\|164414443, gi... - gi\|7716462\|gb\|AAF68387.1\|AF236371_1 prohibitin [Zea mays], gi\|164414443\|ref\|NP_001104969.1\| prohibit...	8.0E-64	[32..300]	[11..279]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-63	[28..300]	[2..275]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRSPGEFQR YAKAFQKQLS KVQQTGGRGQ VPSPRGAFAG LGGLLLLGGG ALFINNALFN  60
   61 VDGGHRAIVY SRIHGVSSRI FNEGTHFIFP WLDTPIIYDV RAKPRNVASL TGTKDLQMVN 120
  121 ITCRVLSRPD VVQLPTIYRT LGQDYDERVL PSIVNEVLKA VVAQFNASQL ITQREKVSRL 180
  181 IRENLVRRAS KFNILLDDVS ITYMTFSP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [237-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKQGMVVRAQ GEAKSAELIG EAIKKSRDYV EL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	770.156545
Match:	1lu7A_
Description:	No description for 1lu7A_ was found.

Predicted Domain #2

Region A:
Residues: [209-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFTNAVEAKQ IAQQDAQRAA FVVDKARQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [269-315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRLDTARDIA KILASSPNRV ILDNEALLLN TVVDARIDGR GQINSEG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	770.156545
Match:	1lu7A_
Description:	No description for 1lu7A_ was found.

Predicted functions:

Term	Confidence	Notes
binding	2.10215477176861	bayes_pls_golite062009
protein binding	0.769979871341236	bayes_pls_golite062009
structural molecule activity	0.591437172549816	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [207-315]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPEFTNAVEA KQIAQQDAQR AAFVVDKARQ EKQGMVVRAQ GEAKSAELIG EAIKKSRDYV  60
   61 ELKRLDTARD IAKILASSPN RVILDNEALL LNTVVDARID GRGQINSEG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: