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Protein Overview: MTO1

General Information:
Name(s) found: MTO1 / YGL236C [SGD]
Description(s) found:
Found 13 descriptions.
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  • Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 679 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    tRNA modification [IMPLink to PubMed article]
    translation [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRVTTLASS CTSFPLQVLR RRLTISSLTS FQPTTKTQVV VIGAGHAGCE AAAASSRTGA  60
   61 HTTLITPSLT DIGKCSCNPS IGGVGKGILV KEIDALDGLM GKVTDLAGVQ FKMLNRSKGP 120
  121 AVWGPRAQID RELYKKYMQR ELSDKKAHPN LSLLQNKVAD LILYDPGCGH KVIKGVVLDD 180
  181 GTQVGADQVI ITTGTFLSAE IHIGDKRIAA GRIGEQPTYG ISNTLQNEVG FQLGRLKTGT 240
  241 PARLAKESID FSALEVQKGD ALPVPMSFLN ETVSVEPTKQ LDCFGTHTTP QMHDFLRNNL 300
  301 HQSIHIQDTT IKGPRYCPSI EAKILRFPDR SSHKIWLEPE GFNSDVIYPN GISNSMPEDV 360
  361 QLQMMRLIPG MANVEILQPA YGVEYDYVDP RQLKPSLETK LVDGLFLAGQ INGTTGYEEA 420
  421 AAQGIIAGIN AGLLSRQERE QLVLKRSEAY IGVLIDDLIN NGVIEPYRMF TSRSEFRISV 480
  481 RADNADFRLT PIGAQLGIIS PVRLSQYSRD KHLYDETIRA LQNFKLSSQK WSSLLQANIA 540
  541 PQAENRSAWE IFRFKDMDLH KLYECIPDLP INLLDIPMHV VTKINIQGKY EPYIVKQNQF 600
  601 VKAFQADENM LLPQDYDYRQ LPTLSTECKL LLNRVQPLTI GQARRIQGIT AAALFELYRV 660
  661 ARSQANQSCK YPLIVSLYM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A No confident structure predictions are available.
    2 View Details [73..135]
    [197..270]    		 PSI-BLAST 32.09691 Dihydrolipoamide dehydrogenase
    3 View Details [136..196] PSI-BLAST 32.09691 Dihydrolipoamide dehydrogenase
    4 View Details [271..331] deduced N/A No confident structure predictions are available.
    5 View Details [332..437] MSA 3.119991 View MSA. Confident ab initio structure predictions are available.
    6 View Details [438..679] MSA 1.088951 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  4.24087829378489 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.84060092432585 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • antioxidant activity
    		•  1.49429830917872 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.39990343076756 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.14701726867934 bayes_pls_golite062009
  • binding
    		•  0.400596507621048 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.36771673037999 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.187016999137115 bayes_pls_golite062009
  • protein binding
    		•  0.139858531143419 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle