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Protein Overview: GPI10

General Information:
Name(s) found: GPI10 / YGL142C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 616 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    Biological Process: GPI anchor biosynthetic process [IMPLink to PubMed article]
    Molecular Function: mannosyltransferase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHEVHRIKP KLGRTQIFWV FLAFRVLNAV LTRTFFQADE FWQALEPAHW KAFKYGELTW  60
   61 EWKFGVRSYL FPMIFELTYR LVSLSSILLH YALLLLSTIG SDLLILLLPK YELSWQVAED 120
  121 LKRLPFDVTR SFEYYGVIYA PKIVMAVLAS IGEYYIVRFV QKLYLLTLDK RNEKEEEERR 180
  181 SGLSEITKFA LLLSLTNFFN CFFITRTFIN SFEMILTSIA LYYWDWTGGQ MIKESSFTKS 240
  241 LIFAFLACLQ RPSSGLIWVI PSISLILNLV GKKQYHLLFI TFSKVLRSFF LVFTANAIID 300
  301 MYFYEKVTFP FFRFLKFNFT TPLSKFYGVA PWHFHFFQSL PIVLGASIPA FAFGLFFPLS 360
  361 KRSFPKKYLN PFFQVKLTIL LNLLVYSTLP HKEFRFIFPL QPLFILISSF GLLRLDRDYW 420
  421 KRLSGLKSLL WLVPFVSVFI ALLLDTFHES GSIEVMKFLH EEPEIDSLGF IMPCHSTPGQ 480
  481 SYLHRSDIQD LWSITCNPPL HLLGDPEAYS KLETYMDESD HLYDDISAFI YKNFPPPFRK 540
  541 DLRSPGKTYS HEWPTYLVVF EHMENAFLKD FLKDSSYIEY NRFFNSLAHW DSRRSGDIII 600
  601 YYKLPFDYSD IPAADI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) ERV25 GPI10

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..616] Pfam 8.130768 Alg9-like mannosyltransferase family No confident structure predictions are available.
    2 View Details [87..227] MSA 5.159996 View MSA. No confident structure predictions are available.
    3 View Details [228..418] MSA 2.161973 View MSA. No confident structure predictions are available.
    4 View Details [419..616] MSA 1.141968 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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